Abstract:
The reaction of 4,5,6,7-tetrahydro-1-benzothiophene derivatives with ethyl acetoacetate gave oxobutanamide derivatives. The reactivity of these products towards some chemical reagents was studied to afford new heterocyclic derivatives. The cytotoxicity of the newly synthesized compounds was evaluated against three human tumor cells lines and three normal cell lines. The results showed that some of these compounds exhibit high inhibitory effects towards the three tumor cell lines and the normal cell lines. � 2013 Springer Science+Business Media New York.
