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| dc.contributor.author | Mohamed A.-M.I. | |
| dc.contributor.author | Abdelmageed O.H. | |
| dc.contributor.author | Salem H. | |
| dc.contributor.author | Nagy D.M. | |
| dc.contributor.author | Omar M.A. | |
| dc.contributor.other | Pharmaceutical Analytical Chemistry Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Assiut University | |
| dc.contributor.other | Assiut | |
| dc.contributor.other | Egypt; Pharmaceutical Chemistry Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | King Abdulaziz University | |
| dc.contributor.other | Jeddah | |
| dc.contributor.other | Saudi Arabia; Pharmaceutical Analytical Chemistry Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | MSA University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Analytical Chemistry Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Minia University | |
| dc.contributor.other | Minia | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:42:24Z | |
| dc.date.available | 2020-01-09T20:42:24Z | |
| dc.date.issued | 2013 | |
| dc.identifier.issn | 15227235 | |
| dc.identifier.other | https://doi.org/10.1002/bio.2388 | |
| dc.identifier.other | PubMed ID 22786713 | |
| dc.identifier.uri | https://t.ly/BX3jM | |
| dc.description | Scopus | |
| dc.description.abstract | A validated simple and sensitive spectrofluorimetric method was developed for the determination of chlorpromazine hydrochloride, promethazine hydrochloride, trifluperazine hydrochloride, thioridazine hydrochloride, perazine maleate and oxomemazine. The method was based on condensation of malonic acid/acetic anhydride (MAA) under the catalytic effect of the tertiary amine moiety of the studied phenothiazines to provide a deep yellow to brown colour with green florescence. Relative fluorescence intensity of the products was measured at ?exc 398 nm and ?em 432 nm. Different variables affecting the reaction were studied and optimized. The method was successfully applied for the determination of the studied drugs in commercial dosage forms. The lower detection limits allowed the application of this method for the determination of the compounds in plasma as an example of a biological fluid. In addition, the method was considered specific for the determination of tertiary amines in the presence of primary and secondary amines; as a result, it was deemed suitable for the determination of the cited drugs in the presence of their degradation products resulting from N-dealkylation or oxidation of the corresponding sulphoxides or sulphones. Copyright � 2012 John Wiley & Sons, Ltd. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=26988&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.relation.ispartofseries | Luminescence | |
| dc.relation.ispartofseries | 28 | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | University for Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | acetic anhydride | en_US |
| dc.subject | dosage forms | en_US |
| dc.subject | malonic acid | en_US |
| dc.subject | phenothiazines | en_US |
| dc.subject | plasma | en_US |
| dc.subject | spectrofluorimetric determination | en_US |
| dc.subject | drug dosage form | en_US |
| dc.subject | neuroleptic agent | en_US |
| dc.subject | phenothiazine derivative | en_US |
| dc.subject | neuroleptic agent | en_US |
| dc.subject | phenothiazine derivative | en_US |
| dc.subject | blood | en_US |
| dc.subject | drug dosage form | en_US |
| dc.subject | evaluation study | en_US |
| dc.subject | human | en_US |
| dc.subject | procedures | en_US |
| dc.subject | spectrofluorometry | en_US |
| dc.subject | article | en_US |
| dc.subject | methodology | en_US |
| dc.subject | spectrofluorometry | en_US |
| dc.subject | Antipsychotic Agents | en_US |
| dc.subject | Dosage Forms | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Phenothiazines | en_US |
| dc.subject | Spectrometry, Fluorescence | en_US |
| dc.subject | Antipsychotic Agents | en_US |
| dc.subject | Dosage Forms | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Phenothiazines | en_US |
| dc.subject | Spectrometry, Fluorescence | en_US |
| dc.title | Spectrofluorimetric determination of certain biologically active phenothiazines in commercial dosage forms and human plasma | en_US |
| dc.type | Article | en_US |
| dcterms.isReferencedBy | Foye, W.O., Williams, D.A., Lemke, T.L., (2002) Foy's Principles of Medicinal Chemistry, p. 412. , 5th edn. Lippincott Williams & Wilkins: Paltimore, USA; Basavaiah, K., Swamy, J.M., Titrimetric and spectrophotometric determination of some phenothiazine psychotropics in pure form and in pharmaceutical formulations with metavanadate (2001) Mikrochim Acta, 137, pp. 75-80; Basavaiah, K., Krishnamurthy, G., Oxidimetric titration of some phenothiazine neuroleptics and antiallergics with potassium dichromate (1999) Anal Sci, 15, pp. 67-71; Basavaiah, K., Krishnamurthy, G., Titrimetric micro determination of some phenothiazines using ferricyanide (1998) Talanta, 47, pp. 665-670; Shamsipur, M., Hemmateenejad, B., Akhond, M., Simultaneous determination of promethazine, chlorpromazine and perphenazine by multivariate calibration and derivative spectrophotometry (2002) Iran J AOAC Int, 85, pp. 555-562; Aman, T., Rashid, A., Khokhar, I., Iqbal, S., Spectrophotometric determination of chlorpromazine (1997) Anal Lett, 30, pp. 109-115; Basavaiah, K., Krishnamurthy, G., Spectrophotometric assay of some antipsychotropic and anticholinergic phenothiazine drugs using ammonium molybdate (1998) Anal Lett, 31, pp. 1037-1046; Mellado, R.A., Gomez, B.C., Martinez, C.J., Photochemical derivatization and fluorimetric determination of promethazine in a FIA assembly (1992) Anal Lett, 25, pp. 1289-1308; Basavaiah, K., Swamy, M., Highly sensitive spectrophotometric method for the determination of some phenothiazine antipsychotics using chloramine-T and indigocarmine (2001) Anal Sci, 17, pp. 963-967; Tarasiewicz, M., Kuymicka, L., Extractive spectrophotometric determinationsl of some phenothiazines with picric and flavianic acids (1996) Anal Lett, 29, pp. 929-936; Starczewska, B., Karpinska, J., Application of eriochrome cyanine R to the extractive -spectrophotometric determination of chlorpromazine (1996) Anal Lett, 29, pp. 2475-2486; Basavaiah, K., Manjunathaswamy, L., Krishnamurthy, G., Spectrophotometric analysis of some phenothiazine neuroleptics using chloramine-T (1999) Anal Lett, 32, pp. 2613-2623; Ramesh, K.C., Gowda, B.G., Melwanki, M.B., Seetharamappa, J., Extractive spectrophotometric determination of antiallergic drugs in pharmaceutical formulations using bromopyrogallol red and bromothymol blue (2001) Anal Sci, 17, pp. 1101-1103; Pournaghi-Azar, M.H., Farhadi, K., Potentiometric study of reaction between tetrabutylammonium periodate and phenothiazine in chloroform (1997) Talanta, 44, pp. 1773-1781; Ni, Y.N., Wang, L., Kokot, S., Voltammetric determination of chlorpromazine hydrochloride and prometazine hydrochloride with the use of multivariate calibration (2001) Anal Chim Acta, 439, pp. 159-168; Kojlo, A., Indirect potentiometric determination of chlorpromazine with an oxidative column in a flow injection system (1997) Anal Lett, 30, pp. 2353-2363; Kojilo, A., Calatayud, J.M., FIA-spectrophotometric determination of N-substituted phenothiazine derivatives by oxidation with a solid-phase reactor of manganese dioxide incorporated in polyester resin beads (1995) Talanta, 42, pp. 909-913; Daniel, D., Gutz, I.G.R., Spectroelectrochemical determination of chlorpromazine hydrochloride by flow-injection analysis (2005) J Pharm Bio Anal, 37, pp. 281-286; Perez-Ruiz, T., Martinez-Lozano, C., Tomas, V., De-Cardona, C.S., Flow-injection fluorimetric determination of trimeprazine and trifluoperazine in pharmaceutical preparations (1993) Talanta, 40, pp. 1361-1365; Romano, A.M., Benito, C.G., Calatayud, J.M., Photochemical derivatization and fluorimetric determination of promethazine in a FIA assembly (1992) Anal Lett, 25, pp. 1289-1308; Sultan, S.M., Hassan, Y.A.M., Abulkibash, A.M., Chemiluminescence assay of promethazine hydrochloride using acidic permanganate employing flow injection mode operated with syringe and peristaltic pumps (2003) Talanta, 59, pp. 1073-1080; Tanaka, E., Nakamura, T., Terada, M., Shinozuka, T., Hashimoto, C., Kurihara, K., Honda, K., Simple and simultaneous determination for 12 phenothiazines in human serum by reversed-phase high-performance liquid chromatography (2007) J Chromatogr B, 854, pp. 116-120; Kirchherr, H., K�hn-Velten, W.N., Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: A multi-level, single-sample approach (2006) J Chromatogr B, 843, pp. 100-113; Larsimont, V., Meins, J., Fieger-B�schges, H., Blume, H., Validated high-performance liquid chromatographic assay for the determination of promazine in human plasma, Application to pharmacokinetic studies (1998) J Chromatogr B, 719, pp. 222-226; Boehme, C.L., Strobel, H.W., High-performance liquid chromatographic methods for the analysis of haloperidol and chlorpromazine metabolism in vitro by purified cytochrome P450 isoforms (1998) J Chromatogr B, 718, pp. 259-266; Zhang, G., Terry Jr., A.V., Bartlett, M.G., Simultaneous determination of five antipsychotic drugs in rat plasma by high performance liquid chromatography with ultraviolet detection (2007) J Chromatogr B, 856, pp. 20-28; Bagli, M., Rao, M.L., H�flich, G., Quantification of chlorprothixene, levomepromazine and promethazine in human serum using high-performance liquid chromatography with coulometric electrochemical detection (1994) J Chromatogr B, 657, pp. 141-148; Ponder, G.W., Stewart, J.T., A liquid chromatographic method for the determination of promethazine enantiomers in human urine and serum using solid-phase extraction and fluorescence detection (1995) J Pharm Bio Anal, 13, pp. 1161-1166; De Gaitani, C.M., Souto Martinez, A., Sueli Bonato, P., Study on thioridazine 5-sulfoxide epimerization and degradation by capillary electrophoresis (2003) Brazil Electrophoresis, 24, pp. 2723-2730; Mounsey, A., Strachan, D., Rowell, F.J., Rowell, V., Tyson, J.D., Direct determination of some phenothiazine sedatives in greyhound urine by fluoroimmunoassay (1996) Analyst, 121, pp. 955-958; Groth, A.B., Wallerberg, G., (1966) Acta Chem Scand, 20, p. 2628; Miller, J.N., Miller, J.C., (2005) Statistical and Chemometric for Analytical Chemistry, , 5th edn. Harlow, England: Pearson Education Limited; Saif, M.J., Anwar, J., A new spectrophotometric method for the determination of promethazine-HCl from pure and pharmaceutical preparations (2005) Talanta, 67, pp. 869-872; (1993) The British Pharmacopoeia, p. 148. , 669, 687 Her Majesty's Stationary Office: London, UK; El-Didamony, A.M., Extractive spectrophotometric methods for the determination of oxomemazine hydrochloride in bulk and pharmaceutical formulations using bromocresol green, bromocresol purple and bromophenol blue (2005) Arch Pharm (Weinheim), 338 (4), pp. 190-197; Brynn, H.D., Justin, G.J., (2006) Data Analysis for Chemistry, p. 37. , 3th edn. New York: Oxoford Univeristy Press Inc. Electronic version; Jefferry, G.H., Bassett, J., Mendham, J., Denney, R.C., (1989) Vogel's Text Book of Quantitative Chemical Analysis, , 5th edn. London: Longman Group UK Limited | |
| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1002/bio.2388 | |
| dc.identifier.doi | PubMed ID 22786713 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
