dc.contributor.author | Abdelkader H. | |
dc.contributor.author | Abdallah O.Y. | |
dc.contributor.author | Salem H. | |
dc.contributor.author | Alani A.W.G. | |
dc.contributor.author | Alany R.G. | |
dc.contributor.other | Department of Pharmaceutics | |
dc.contributor.other | Faculty of Pharmacy | |
dc.contributor.other | Minia University | |
dc.contributor.other | Minia | |
dc.contributor.other | Egypt; Department of Pharmaceutics | |
dc.contributor.other | Faculty of Pharmacy | |
dc.contributor.other | Alexandria University | |
dc.contributor.other | Alexandria | |
dc.contributor.other | Egypt; Analytical Chemistry Department | |
dc.contributor.other | Faculty of Pharmacy | |
dc.contributor.other | October University for Modern Science and Arts | |
dc.contributor.other | Cairo | |
dc.contributor.other | Egypt; Department of Pharmaceutical Sciences | |
dc.contributor.other | College of Pharmacy | |
dc.contributor.other | Oregon State University | |
dc.contributor.other | Corvallis | |
dc.contributor.other | OR | |
dc.contributor.other | United States; School of Pharmacy and Chemistry | |
dc.contributor.other | Kingston University London | |
dc.contributor.other | Kingston upon Thames | |
dc.contributor.other | United Kingdom; School of Pharmacy | |
dc.contributor.other | University of Auckland | |
dc.contributor.other | Auckland | |
dc.contributor.other | New Zealand | |
dc.date.accessioned | 2020-01-09T20:42:06Z | |
dc.date.available | 2020-01-09T20:42:06Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 223573 | |
dc.identifier.other | https://doi.org/10.1111/jphp.12277 | |
dc.identifier.other | PubMed ID 24944002 | |
dc.identifier.uri | https://t.ly/NXNwx | |
dc.description | Scopus | |
dc.description.abstract | Objectives The solid-state interactions of fused mixtures nimesulide (ND) with polyethylene glycol (PEG) 4000, urea or mannitol were studied through constructing thaw-melt phase equilibrium diagrams. Methods The solid-state characteristics were investigated using differential scanning calorimetry (DSC) and X-ray diffraction (XRD). Various types of interactions were identified such as the formation of a eutectic system of ND-PEG 4000, monotectic system of ND-urea and complete solid immiscibility of ND with mannitol. The effects of carrier concentrations on the equilibrium solubility and in-vitro dissolution characteristics were studied. Key findings Linear increases (R2 > 0.99) in the aqueous solubility of ND in various concentrations of PEG 4000 and urea were obtained, whereas mannitol did not exhibit any effect on the solubility of ND. Similar trends were obtained with the dissolution efficiency of the fused mixtures of ND with PEG 4000 and urea compared with the corresponding physical mixtures and untreated drug. The analgesic effects of untreated ND and the selected formulations were investigated by evaluating the drug's ability to inhibit the acetic acid-induced writhing response. Conclusions The analgesic effect of ND in a eutectic mixture with PEG 4000 and a monotectic mixture with urea was potentiated by 3.2 and 2.7-fold respectively compared with the untreated drug. � 2014 Royal Pharmaceutical Society. | en_US |
dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=23102&tip=sid&clean=0 | |
dc.language.iso | English | en_US |
dc.publisher | Blackwell Publishing Ltd | en_US |
dc.relation.ispartofseries | Journal of Pharmacy and Pharmacology | |
dc.relation.ispartofseries | 66 | |
dc.subject | dissolution rate | en_US |
dc.subject | eutectic | en_US |
dc.subject | monotectic | en_US |
dc.subject | nimesulide | en_US |
dc.subject | solubility | en_US |
dc.subject | acetic acid | en_US |
dc.subject | drug carrier | en_US |
dc.subject | excipient | en_US |
dc.subject | macrogol derivative | en_US |
dc.subject | nimesulide | en_US |
dc.subject | povidone | en_US |
dc.subject | prostaglandin synthase inhibitor | en_US |
dc.subject | sulfonamide | en_US |
dc.subject | urea | en_US |
dc.subject | water | en_US |
dc.subject | animal | en_US |
dc.subject | chemically induced | en_US |
dc.subject | chemistry | en_US |
dc.subject | differential scanning calorimetry | en_US |
dc.subject | medicinal chemistry | en_US |
dc.subject | mouse | en_US |
dc.subject | pain | en_US |
dc.subject | solubility | en_US |
dc.subject | X ray diffraction | en_US |
dc.subject | Acetic Acid | en_US |
dc.subject | Animals | en_US |
dc.subject | Calorimetry, Differential Scanning | en_US |
dc.subject | Chemistry, Pharmaceutical | en_US |
dc.subject | Cyclooxygenase Inhibitors | en_US |
dc.subject | Drug Carriers | en_US |
dc.subject | Excipients | en_US |
dc.subject | Mice | en_US |
dc.subject | Pain | en_US |
dc.subject | Polyethylene Glycols | en_US |
dc.subject | Povidone | en_US |
dc.subject | Solubility | en_US |
dc.subject | Sulfonamides | en_US |
dc.subject | Urea | en_US |
dc.subject | Water | en_US |
dc.subject | X-Ray Diffraction | en_US |
dc.title | Eutectic, monotectic and immiscibility systems of nimesulide with water-soluble carriers: Phase equilibria, solid-state characterisation and in-vivo/pharmacodynamic evaluation | en_US |
dc.type | Article | en_US |
dcterms.isReferencedBy | Vo, C.L., Current trends and future perspectives of solid dispersions containing poorly water-soluble drugs (2013) Eur J Pharm Biopharm, 85, pp. 799-813; Abdelkader, H., Comparison of the effect of tromethamine and polyvinylpyrrolidone on dissolution properties and analgesic effect of nimesulide (2007) AAPS PharmSciTech, 8, pp. E1-E8; Dressman, J.B., Dissolution testing as a prognostic tool for oral drug absorption: Immediate release dosage forms (1998) Pharm Res, 15, pp. 11-22; Singh, A., Nimesulide (2001) Analytical Profiles of Drug Substances and Excipients, pp. 198-249. , Brittain H.G. ed. 28. New York: Academic Press; Singla, A., Nimesulide: Some pharmaceutical and pharmacological aspects-an update (2000) J Pharm Pharmacol, 52, pp. 467-475; (2002) WHO Pharmaceuticals Newsletter No. 04, pp. 1-19. , WHO; Piel, G., Study of the influence of both cyclodextrins and L-lysine on the aqueous solubility of nimesulide: Isolation and characterization of nimesulide-L-lysine-cyclodextrin complexes (1997) J Pharm Sci, 86, pp. 475-480; Chowdary, K., Nalluri, B., Nimesulide and beta-cyclodextrin inclusion complexes: Physicochemical characterization and dissolution rate studies (2000) Drug Dev Ind Pharm, 26, pp. 1217-1220; Shobha, R.H., Formulation and disolution rate of solid dispersion of nimesulide (1998) Indian J Pharm Sci, 60, pp. 326-327; Chiou, W.L., Mechanism of increased rates of dissolution and oral absorption of chloramphenicol from chloramphenicol-urea solid dispersion system (1971) J Pharm Sci, 60, pp. 1406-1408; Abdelkader, H., Formulation of controlled-release Baclofen matrix tablets II: Influence of some hydrophobic excipients on the release rate and in vitro evaluation (2008) AAPS PharmSciTech, 9, pp. 675-683; Maulding, H.V., Solid-state dispersions employing urethan (1978) J Pharm Sci, 67, pp. 391-394; Kaur, R., Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide I: Phase equilibria (1980) J Pharm Sci, 69, pp. 1317-1321; Abdelkader, H., (2006) Improvement and Evaluation of Some Formulations for Skeletal Muscle Drugs, , Master Thesis. Minia, Egypt: Pharmaceutics Department, Minia University; Goldberg, A.H., Increasing dissolution rates and gastrointestinal absorption of drugs via solid solutions (1966) J Pharm Sci, 55, pp. 581-583; Khan, K.A., The concept of dissolution efficiency (1975) J Pharm Pharmacol, 27, pp. 48-49; Adhage, N., Vavia, P., ?-cyclodextrin inclusion complexation by milling (2000) Pharm Pharmacol Commun, 6, pp. 13-17; Inoue, K., Anti-inflammatory effects of etodolac: Comparison with other non-steroidal anti-inflammatory drugs (1994) Biol Pharm Bull, 17, pp. 1577-1583; Tanaka, R., Pharmacological studies of the new anti-inflammatory agent 3-formyl amino-7-methylsulfonyl amino-6-phenoxy 4 H-1-benzopyran-4-one (1992) Arzneimittelforschung, 42, pp. 935-944; Kaur, R., Comparison of polyethylene glycol and polyoxyethylene stearate as excipients for solid dispersion systems of griseofulvin and tolbutamide I: Phase equilibria (1980) J Pharm Sci, 69, pp. 1317-1321; Craig, D.Q.M., Polyethylene glycols and drug release (1990) Drug Dev Ind Pharm, 16, pp. 2501-2526; Schroeder, H.G., Sustained release from inert wax matrixes I: Drug-wax combinations (1978) J Pharm Sci, 67, pp. 350-353; Rogers, J.A., Anderson, A.J., Physical characteristics and dissolution profiles of ketoprofen-urea solid dispersions (1982) Pharm Acta Helv, 57, pp. 276-281; Chiou, W.L., Niazi, S., Pharmaceutical applications of solid dispersion systems: Dissolution of griseofulvin-succinic acid eutectic mixture (1976) J Pharm Sci, 65, pp. 1212-1214; Lippold, B.C., Ohm, A., Correlation between wettability and dissolution rate of pharmaceutical powders (1986) Int J Pharm, 29, pp. 67-74; El-Banna, H.M., Abdullah, O.Y., Physicochemical and dissolution studies of phenylbutazone binary systems (1980) Pharm Acta Helv, 55, pp. 256-260; Habib, F.S., Attia, M.A., Effect of particle size on the dissolution rate of monophenylbutazone solid dispersion in presence of additives (1985) Drug Dev Ind Pharm, 11, pp. 2009-2019; Chiou, W.L., Riegelman, S., Preparation and dissolution characteristics of several fast-release solid dispersions of griseofulvin (1969) J Pharm Sci, 58, pp. 1505-1510; Alonso, M.J., A comparative biopharmaceutical study of fresh and ageing tolbutamide-polyethyleneglycols solid dispersions (1988) Int J Pharm, 41, pp. 27-33 | |
dcterms.source | Scopus | |
dc.identifier.doi | https://doi.org/10.1111/jphp.12277 | |
dc.identifier.doi | PubMed ID 24944002 | |
dc.Affiliation | October University for modern sciences and Arts (MSA) |