Chemical and biological investigation of essential oil of oroxylum indicum L. Leaves cultivated in Egypt

Zaghloul S.S.; Azzam S.M.; Eid H.H.; Hassan H.A.; Sleem A.A.

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Chemical and biological investigation of essential oil of oroxylum indicum L. Leaves cultivated in Egypt

Zaghloul S.S.; Azzam S.M.; Eid H.H.; Hassan H.A.; Sleem A.A.

Full Text link: https://t.ly/mbe7A

Date issued: 2015

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Doi: https://doi.org/

Publisher: International Journal of Pharmacognosy and Phytochemical Research

Series Info: International Journal of Pharmacognosy and Phytochemical Research
7

Type: Article

Keywords: Antioxidant , Cytotoxic , Essential oil , Hepatoprotective and hepatocurative activity , Oroxylum indicum L , alanine aminotransferase , alkaline phosphatase , alpha tocopherol , amphotericin B , ascorbic acid , aspartate aminotransferase , essential oil , silymarin , tetracycline , adult , alanine aminotransferase blood level , alkaline phosphatase blood level , alloxan-induced diabetes mellitus , animal experiment , animal model , antimicrobial activity , antineoplastic activity , antioxidant activity , Article , aspartate aminotransferase blood level , Aspergillus niger , Bacillus subtilis , breast carcinoma , Candida albicans , concentration (parameters) , concentration response , controlled study , cytotoxicity , DPPH radical scavenging assay , drug activity , Egypt , Escherichia coli , HeLa cell line , hepatocurative activity , HepG2 cell line , hydrodistillation , in vitro study , in vivo study , liver cell carcinoma , liver protection , male , mass fragmentography , MCF 7 cell line , nonhuman , Oroxylum , oxygenation , phytochemistry , plant leaf , Pseudomonas aeruginosa , rat , Staphylococcus aureus , uterine cervix carcinoma

Abstract:

Hydrodistilled essential oil of fresh leaves of Oroxylum indicum L. family Bignoniaceae cultivated in Egypt was analyzed by gas chromatography?mass spectrometry (GC/MS) .The yield of essential oil was (0.2 %) . Thirty nine components were identified representing (89.85%). Ar-tumerone (19.37%), a sesquiterpene ketone, was the major constituent in the oil followed by methyl hexadecanoate (6.2%), laurenan-2-one (5.59%) and isopropyl butanoate (5.57%). The oxygenated constituents represents (63.81 %) while non- oxygenated constituents represents (26.04 %) .The oil showed significant cytotoxic activity on MCF7 (breast carcinoma cell line), HEPG2 (liver carcinoma cell line) and HELA (cervix carcinoma cell line) ,in addition to good in vivo and in vitro antioxidant activity. The oil also exhibited both hepatoprotective and heptocurative action, but showed weak antimicrobial activity against tested bacteria with no effect against fungi. � 2015, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.