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| dc.contributor.author | Bakr R.O. | |
| dc.contributor.author | El Bishbishy M.H. | |
| dc.contributor.other | Pharmacognosy Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:40Z | |
| dc.date.available | 2020-01-09T20:41:40Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 0102695X | |
| dc.identifier.other | https://doi.org/10.1016/j.bjp.2016.04.001 | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/dOgp6 | |
| dc.description | Scopus | |
| dc.description.abstract | The present study was designed to investigate polyphenolic and sulphur contents of the aerial parts of Capparis spinosa var.aegyptia (Lam.) Boiss., Capparaceae, wildly growing in Egypt.The chemical compositions of the water distilled essential oil were investigated by GC/MS analysis where the major constituent of the oil was methyl isothiocyanate (24.66%).Hydroethanolic extract was evaluated by LC-HRESI-MS-MS in both positive and negative modes.Forty-two compounds were identified including quercetin, kaempferol and isorhamnetin derivatives in addition to myricetin, eriodictyol, cirsimaritin and gallocatechin derivatives.Quercetin tetrahexoside dirhamnoside as well as kaempferol dihexoside dirhamnoside have not been identified before in genus Capparis.Phenolic acids, such as quinic acid, p-coumaroyl quinic acid and chlorogenic acid were also identified.Evaluation of cytotoxic activity of hydroethanolic extract against three human cancer cell lines (MCF-7; breast adenocarcinoma cells, Hep-G2; hepatocellular carcinoma cells and HCT-116; colon carcinoma) using 3-[4,5-dimethylthiazole-2-yl]-2,5-diphenyltetrazolium bromide (MTT) assay showed significant effect with IC50 values 24.5, 24.4 and 11 g/ml, compared to Doxorubicin as a standard cytotoxic drug.C.spinosa revealed itself as a promising candidate for nutraceutical researches. 2016 Sociedade Brasileira de Farmacognosia. | en_US |
| dc.language.iso | English | en_US |
| dc.publisher | Sociedade Brasileira de Farmacognosia | en_US |
| dc.relation.ispartofseries | Brazilian Journal of Pharmacognosy | |
| dc.relation.ispartofseries | 26 | |
| dc.subject | Capparis spinosa | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.subject | Flavonoids | en_US |
| dc.subject | Isothiocyanate | en_US |
| dc.subject | LC-HRESI-MS-MS | en_US |
| dc.subject | 4 coumaroyl quinic acid | en_US |
| dc.subject | absinthol | en_US |
| dc.subject | camphor | en_US |
| dc.subject | Capparis spinosa extract | en_US |
| dc.subject | caryophyllene | en_US |
| dc.subject | chlorogenic acid | en_US |
| dc.subject | cirsimaritin | en_US |
| dc.subject | copaene | en_US |
| dc.subject | doxorubicin | en_US |
| dc.subject | eriodictyol | en_US |
| dc.subject | essential oil | en_US |
| dc.subject | gallocatechin | en_US |
| dc.subject | gamma muurolene | en_US |
| dc.subject | glucosinolate | en_US |
| dc.subject | humulene | en_US |
| dc.subject | isopropyl isothiocyanate | en_US |
| dc.subject | isorhamnetin | en_US |
| dc.subject | kaempferol | en_US |
| dc.subject | kaempferol dihexoside dirhamnoside | en_US |
| dc.subject | methyl isothiocyanate | en_US |
| dc.subject | myricetin | en_US |
| dc.subject | para cymene | en_US |
| dc.subject | plant extract | en_US |
| dc.subject | plant medicinal product | en_US |
| dc.subject | quercetin | en_US |
| dc.subject | quercetin tetrahexoside dirhamnoside | en_US |
| dc.subject | quinic acid | en_US |
| dc.subject | spathulenol | en_US |
| dc.subject | sulforaphane | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | unindexed drug | en_US |
| dc.subject | antineoplastic activity | en_US |
| dc.subject | Article | en_US |
| dc.subject | Capparis spinosa | en_US |
| dc.subject | chemical composition | en_US |
| dc.subject | collisionally activated dissociation | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | cytotoxicity | en_US |
| dc.subject | electrospray mass spectrometry | en_US |
| dc.subject | herbal medicine | en_US |
| dc.subject | high performance liquid chromatography | en_US |
| dc.subject | human | en_US |
| dc.subject | human cell | en_US |
| dc.subject | mass fragmentography | en_US |
| dc.subject | MTT assay | en_US |
| dc.subject | plant structures | en_US |
| dc.title | Profile of bioactive compounds of Capparis spinosa var.Aegyptiaca growing in Egypt | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1016/j.bjp.2016.04.001 | |
| dc.identifier.doi | PubMed ID : | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
