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| dc.contributor.author | Abd-Elbaky A.E. | |
| dc.contributor.author | Abo-ElMatty D.M. | |
| dc.contributor.author | Mesbah N.M. | |
| dc.contributor.author | Ibrahim S.M. | |
| dc.contributor.other | Biochemistry Department | |
| dc.contributor.other | Port Said University | |
| dc.contributor.other | Port Said | |
| dc.contributor.other | Egypt; Biochemistry Department | |
| dc.contributor.other | Suez Canal University | |
| dc.contributor.other | Ismailia | |
| dc.contributor.other | Egypt; Biochemistry Department | |
| dc.contributor.other | Modern Sciences and Arts University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:38Z | |
| dc.date.available | 2020-01-09T20:41:38Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 9733930 | |
| dc.identifier.other | https://doi.org/10.1007/s13410-015-0416-y | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/zNMKV | |
| dc.description | Scopus | |
| dc.description.abstract | Dysregulation of omentin, a beneficial adipokine, and apelin, an inflammatory adipokine, is thought to play a role in the development of type 2 diabetes mellitus and cardiovascular disease. The objective of this study was to evaluate the relationship between circulating omentin and apelin concentrations and components of the metabolic syndrome in adults with and without type 2 diabetes mellitus or cardiovascular disease. A total of 240 adults, sex- and age-matched, were included in the current case�control study, including 80 healthy, non-obese controls, 80 obese patients with T2DM without cardiovascular disease, and 80 obese patients with T2DM with cardiovascular disease. A fasting blood sample was collected to determine biochemical indicators and insulin resistance index (HOMA-IR). Omentin, apelin, interleukin-1? (IL-1?), troponin-T, and oxidized LDL (Ox-LDL) plasma level was assessed by ELISA. Associations of adipokines with biochemical parameters of the patients were determined. Serum omentin levels were significantly lower and serum apelin and IL-1? concentrations were significantly higher in obese diabetic groups compared to non-obese controls. In correlation analyses, omentin negatively associated with the HOMA-IR index, apelin, and troponin-T, whereas apelin was positively associated with IL-1?, BMI, and troponin-T. Our study supports the hypothesis that abnormal production of omentin and apelin can contribute to the pathogenesis of obesity-related complications including T2DM and cardiovascular disease. � 2015, Research Society for Study of Diabetes in India. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=4700152901&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.publisher | Springer India | en_US |
| dc.relation.ispartofseries | International Journal of Diabetes in Developing Countries | |
| dc.relation.ispartofseries | 36 | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | University of Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | Apelin | en_US |
| dc.subject | Cardiovascular disease | en_US |
| dc.subject | IL-1? | en_US |
| dc.subject | Obesity | en_US |
| dc.subject | Omentin | en_US |
| dc.subject | Ox-LDL | en_US |
| dc.subject | Troponin-T | en_US |
| dc.subject | Type 2 diabetes mellitus | en_US |
| dc.title | Omentin and apelin concentrations in relation to obesity, diabetes mellitus type two, and cardiovascular diseases in Egyptian population | en_US |
| dc.type | Article | en_US |
| dcterms.isReferencedBy | Suresh, S., Mahendra, J., Multifactorial relationship of obesity and periodontal disease (2014) J Clin Diagn Res, 8, pp. 1-3; Al-husseini, N., Arafat, N., Mohammed, E., Allam, M., Effect of exercise training on adiponectin receptor expression and insulin resistance in mice fed a high fat diet (2010) Am J Biochem Biotechnol, 6, pp. 77-83. , COI: 1:CAS:528:DC%2BC3cXhtlGjsLrK; Odegaard, J.I., Chawla, A., Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis (2013) Science, 339, pp. 172-177. , COI: 1:CAS:528:DC%2BC3sXjvVCmsg%3D%3D, PID: 23307735; Shaw, J.E., Sicree, R.A., Zimmet, P.Z., Global estimates of the prevalence of diabetes for 2010 and 2030 (2010) Diabetes Res Clin Pract, 87, pp. 4-14. , COI: 1:STN:280:DC%2BC3c%2Fot1Witg%3D%3D, PID: 19896746; Horwich, T., Fonarow, G., Glucose, obesity, metabolic syndrome, and diabetes: relevance to incidence of heart failure (2010) J Am Coll Cardiol, 55, pp. 283-293. , COI: 1:CAS:528:DC%2BC3cXisFertr4%3D, PID: 20117431; Rabe, K., Lehrke, M., Parhofer, K.G., Broedl, U.C., Adipokines and insulin resistance (2008) Mol Med, 14, pp. 741-751. , COI: 1:CAS:528:DC%2BD1cXhsVOgu7jN, PID: 19009016; Bays, H.E., Sick fat, metabolic disease and atherosclerosis (2009) Am J Med, 122, pp. 26-37. , COI: 1:CAS:528:DC%2BD1cXhsFChu7vP, PID: 19110085; Bluher, M., Adipose tissue dysfunction in obesity (2009) Exp Clin Endocrinol Diabetes, 117, pp. 241-250. , COI: 1:STN:280:DC%2BD1MvgsVKhsQ%3D%3D, PID: 19358089; Mattu, H.S., Randeva, H.S., Role of adipokines in cardiovascular disease (2013) J Endocrinol, 216, pp. 17-36; Pan, H.Y., Guo, L., Li, Q., Changes of serum omentin-1 levels in normal subjects and in patients with impaired glucose regulation and with newly diagnosed and untreated type 2 diabetes (2010) Diabetes Res Clin Pract, 88, pp. 29-33. , COI: 1:CAS:528:DC%2BC3cXjtFyjsLc%3D, PID: 20129687; Zhou, J.Y., Chan, L., Zhou, S.W., (2014) Omentin: linking metabolic syndrome and cardiovascular disease, 12, pp. 136-143; Castan-Laurell, I., Dray, C., Knauf, C., Kunduzova, O., Valet, P., Apelin, a promising target for type 2 diabetes treatment (2012) Trends Endocrinol Metab, 23, pp. 234-241. , COI: 1:CAS:528:DC%2BC38XksFensLk%3D, PID: 22445464; Erdem, G., Dogru, T., Tasci, I., Sonmez, A., Tapan, S., Low plasma apelin levels in newly diagnosed type 2 diabetes mellitus (2008) Exp Clin Endocrinol Diabetes, 116, pp. 289-292. , COI: 1:CAS:528:DC%2BD1cXovVSlu7g%3D, PID: 18484561; Machura, E., Szczepanska, M., Ziora, K., Ziora, D., Swietochowska, E., Evaluation of adipokines: apelin, visfatin, and resistin in children with atopic dermatitis (2013) Mediat Inflamm, 2013, pp. 119-127; Manica-Cattani, M.F., Bittencourt, L., Rocha, M.I., Algarve, T.D., Bodanese, L.C., Rech, R., Association between interleukin-1 beta polymorphism and obesity (2010) Mol Cell Endocrinol, 314, pp. 84-89. , COI: 1:CAS:528:DC%2BD1MXhtlWhtrvJ, PID: 19666082; Pitkin, S.L., Modulation of the apelin system in heart failure and atherosclerosis in human (2010) Br J Pharmacol, 160, pp. 1785-1795. , COI: 1:CAS:528:DC%2BC3cXhtlSju7rF, PID: 20649580; Mojtaba, E., Shahram, S., Heshmatolah, P., Alireza, Z., Pro-inflammatory cytokine interleukin-1 beta is associated with cardiovascular fitness in sedentary diabetic patients (2011) J Biodivers Environ Sci, 1, pp. 37-44; Zhao, G., Dharmadhikari, G., Maedler, K., Meyer-Hermann, M., Possible role of interleukin-1? in type 2 diabetes onset and implications for anti-inflammatory therapy strategies (2014) PLoS Comput Biol, 10, pp. 100-108; Trinder, P., Determination of blood glucose using an oxidase-peroxidase system with a non-carcinogenic chromogen (1969) J Clin Pathol, 22, pp. 158-161. , COI: 1:CAS:528:DyaF1MXhtFaht7o%3D, PID: 5776547; Richmond, W., Preparation and properties of a cholesterol oxidase from Nocardia sp. and its application to the enzymatic assay of total cholesterol in serum (1973) Clin Chem, 19, pp. 1350-1356. , COI: 1:CAS:528:DyaE2cXht12ksrg%3D, PID: 4757363; Siedel, J., Hagele, E.O., Ziegenhorn, J., Wahlefeld, A.W., Reagent for the enzymatic determination of serum total cholesterol with improved lipolytic efficiency (1983) Clin Chem, 29, pp. 1075-1080. , COI: 1:CAS:528:DyaL3sXksV2ktb0%3D, PID: 6851096; Burstein, M., Scholnick, H.R., Morfin, R., Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions (1970) J Lipid Res, 11, pp. 583-595. , COI: 1:CAS:528:DyaE3MXpsFw%3D, PID: 4100998; Hatch, F.T., Lees, R.S., Practical methods for plasma lipoprotein analysis (1968) Adv Lipid Res, 6, pp. 1-68. , COI: 1:CAS:528:DyaE3cXjvFGqsQ%3D%3D, PID: 4179999; Matthews, D.R., Hosker, J.P., Rudenski, A.S., Naylor, B.A., Teacher, D.F., Turner, R.C., Homeostasis model assessment: insulin resistance and b cell function from fasting plasma glucose and insulin concentration in man (1985) Diabetologia, 28, pp. 412-419. , COI: 1:CAS:528:DyaL2MXlslKnu7k%3D, PID: 3899825; Chen, C.N., Li, Y.S.J., Yeh, Y.T., Lee, P.L., Synergistic roles of platelet-derived growth factor-BB and interleukin-1-beta in phenotypic modulation of human aortic smooth muscle cells (2006) Proc Nat Acad Sci, 103, pp. 2665-2670. , COI: 1:CAS:528:DC%2BD28XksF2rsbc%3D, PID: 16477012; Tan, B.K., Adya, R., Farhatullah, S., Lewandowski, K.C., O�Hare, P., Lehnert, H., Omentin?1, a novel adipokine, is decreased in overweight insulin resistant women with the polycystic ovary syndrome: ex vivo and in vivo regulation of omentin?1 by insulin and glucose (2008) Diabetes, 57, pp. 801-808. , COI: 1:CAS:528:DC%2BD1cXksVGktLY%3D, PID: 18174521; Principe, A., Melgar-Lesmes, P., Fern�ndez-Varo, G., Del Arbol, L.R., Ros, J., Bernardi, M., The hepatic apelin system: a new therapeutic target for liver disease (2008) Hepatology, 48, pp. 1193-1201. , COI: 1:CAS:528:DC%2BD1cXht1Khu7%2FP, PID: 18816630; Mirzaei, K., Hossein-Nezhad, A., Aslani, S., Emamgholipour, S., Karimi, M., Energy expenditure regulation via macrophage migration inhibitory factor (MIF) in obesity and in vitro anti-MIF effect of Alpinia officinarum Hance extraction (2011) Endocr Pract, 18, pp. 39-48; Van, R.E., Jankowski, C.M., Gozansky, W.S., Schwartz, R.S., Kohrt, W.M., Lower-body adiposity and metabolic protection in postmenopausal women (2005) J Clin Endocrinol Metab, 90, pp. 4573-4578; Casper, G., Coen, D.A., Vascular complications in diabetes mellitus: the role of endothelial dysfunction (2005) Clin Sci, 109, pp. 143-159; Caballero, A.E., Endothelial dysfunction in obesity and insulin resistance: a road to diabetes and heart disease (2003) Obes Res, 11, pp. 1278-1289. , COI: 1:CAS:528:DC%2BD3sXpvFOksbY%3D, PID: 14627747; Arthur, S., Ulf, G., Dyslipidemia and risk of coronary heart disease: role of lifestyle approaches for its management (2009) Am J Life Style Med, 3, pp. 257-273; Defilippi, C.R., de Lemos, J.A., Christenson, R.H., Gottdiener, J.S., Kop, W.J., Zhan, M., Association of serial measures of cardiac troponin T using a sensitive assay with incident heart failure and cardiovascular mortality in older adults (2010) JAMA, 304, pp. 2494-2502. , COI: 1:CAS:528:DC%2BC3cXhsFKjsrnL, PID: 21078811; DeNardo, D., Latz, E., NLRP3 inflammasomes link inflammation and metabolic disease (2011) Trends Immunol, 32, pp. 373-379. , COI: 1:CAS:528:DC%2BC3MXpvFGgsrc%3D; Ohashi, K., Shibata, R., Murohara, T., Ouchi, N., Role of anti-inflammatory adipokines in obesity related diseases (2014) Trends Endocrinol Metab, 25, pp. 348-355. , COI: 1:CAS:528:DC%2BC2cXmsVCksbY%3D, PID: 24746980; Shibata, R., Ouchi, N., Kikuchi, R., Takahashi, R., Takeshita, K., Kataoka, Y., Circulating omentin is associated with coronary artery disease in men (2011) Atherosclerosis, 219, pp. 811-814. , COI: 1:CAS:528:DC%2BC3MXhsFCqsrrO, PID: 21925659; Zhong, X., Zhang, H.Y., Tan, H., Zhou, Y., Liu, F.L., Association of serum omentin-1 levels with coronary artery disease (2011) Acta Pharmacol Sin, 32, pp. 873-878. , COI: 1:CAS:528:DC%2BC3MXotlequrk%3D, PID: 21602837; Moreno-Navarrete, J.M., Catalan, V., Ortega, F., Gomez-Ambrosi, J., Ricart, W., Circulating omentin concentration increases after weight loss (2010) Nutr Metab, 7, pp. 27-38; Yang, R.Z., Lee, M.J., Hu, H., Pray, J., Wu, H.B., Hansen, B.C., Identification of omentin as a novel depot specific adipokine in human adipose tissue: possible role in modulating insulin action (2006) Am J Physiol Endocrinol Metab, 290, pp. 1253-1261; Soriguer, F., Garrido-Sanchez, L., Garcia-Serrano, S., Garcia-Almeida, J.M., Garcia-Arnes, J., Apelin levels are increased in morbidly obese subjects with type 2 diabetes mellitus (2009) Obes Surg, 19, pp. 1574-1580. , PID: 19756893; Dray, C., Debard, C., Jager, J., Disse, E., Daviaud, D., Martin, P., Apelin and APJ regulation in adipose tissue and skeletal muscle of type 2 diabetic mice and humans (2010) Am J Physiol Endocrinol Metab, 298, pp. 1161-1169; Higuchi, K., Masaki, T., Gotoh, K., Chiba, S., Katsuragi, I., Tanaka, K., Apelin, an APJ receptor ligand, regulates body adiposity and favors the messenger ribonucleic acid expression of uncoupling proteins in mice (2007) Endocrinology, 148, pp. 2690-2697. , COI: 1:CAS:528:DC%2BD2sXmt1ajt7s%3D, PID: 17347313; Beltowski, J., Apelin and visfatin: unique �beneficial� adipokines up-regulated in obesity (2006) Med Sci Monit, 12, pp. 112-119; Attane, C., Daviaud, D., Dray, C., Apelin stimulates glucose uptake but not lipolysis in human adipose tissue ex vivo (2011) J Mol Endocrinol, 46, pp. 21-28. , COI: 1:CAS:528:DC%2BC3MXjt1ahsrk%3D, PID: 21062936; Garcia-Diaz, D., Campion, J., Milagro, F.I., Martinez, J.A., Adiposity dependent apelin gene expression: relationships with oxidative and inflammation markers (2007) Mol Cell Biochem, 305, pp. 87-94. , COI: 1:CAS:528:DC%2BD2sXhtFSksLvE, PID: 17594060 | |
| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1007/s13410-015-0416-y | |
| dc.identifier.doi | PubMed ID : | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
