Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity

El Newahie A.M.S.; Ismail N.S.M.; Abou El Ella D.A.; Abouzid K.A.M.

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Quinoxaline-Based Scaffolds Targeting Tyrosine Kinases and Their Potential Anticancer Activity

El Newahie A.M.S.; Ismail N.S.M.; Abou El Ella D.A.; Abouzid K.A.M.

Full Text link: https://t.ly/6xwGP

Date issued: 2016

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Doi: https://doi.org/10.1002/ardp.201500468 PubMed ID 27062086

Publisher: Wiley-VCH Verlag

Series Info: Archiv der Pharmazie
349

Type: Review

Keywords: Anticancer , Kinase inhibitors , Quinoxalines , SAR , Synthetic strategies , antineoplastic agent , cyclin dependent kinase 1 , cyclin dependent kinase 2 , cyclin dependent kinase 4 , cyclin dependent kinase 6 , doxorubicin , Janus kinase 2 inhibitor , protein kinase inhibitor , protein tyrosine kinase inhibitor , quinoxaline derivative , vasculotropin inhibitor , antineoplastic agent , protein kinase inhibitor , protein tyrosine kinase , quinoxaline derivative , antineoplastic activity , biological activity , drug cytotoxicity , drug synthesis , drug targeting , human , nonhuman , priority journal , Review , structure activity relation , antagonists and inhibitors , chemical structure , chemistry , molecular model , synthesis , Antineoplastic Agents , Humans , Models, Molecular , Molecular Structure , Protein Kinase Inhibitors , Protein-Tyrosine Kinases , Quinoxalines , Structure-Activity Relationship

Abstract:

Quinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date. � 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.