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| dc.contributor.author | Zaafan M.A. | |
| dc.contributor.author | Zaki H.F. | |
| dc.contributor.author | El-Brairy A.I. | |
| dc.contributor.author | Kenawy S.A. | |
| dc.contributor.other | Pharmacology & Toxicology Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Pharmacology & Toxicology Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:30Z | |
| dc.date.available | 2020-01-09T20:41:30Z | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1902148 | |
| dc.identifier.other | https://doi.org/10.1080/01902148.2016.1244578 | |
| dc.identifier.other | PubMed ID 27797599 | |
| dc.identifier.uri | https://t.ly/BXOqX | |
| dc.description | Scopus | |
| dc.description.abstract | Objective: The current study aimed to investigate the modulatory effects of pyrrolidinedithiocarbamate (PDTC; 100. mg/kg) on bleomycin-induced pulmonary fibrosis (5�mg/kg; intratracheal) in rats. Materials and Methods: Rats were randomly assigned to three groups: normal control, bleomycin control, and PDTC-treated groups. Lung injury was evaluated through histological examination, immunohistochemical detection of inducible nitric oxide synthase (iNOS) in lung tissue and evaluating the total and differential leucocytes count in bronchoalveolar lavage fluid. Lung tissue was used for biochemical assessment of lung content of hydroxyproline, transforming growth factor beta-1 (TGF-?1), tumor necrosis factor-alpha (TNF-?) as well as analysis of lipid peroxides, reduced glutathione (GSH), and total nitrite contents. Results: PDTC attenuated bleomycin-induced pulmonary fibrosis as evidenced by histological observations, decreased iNOS expression and prevention of bleomycin-induced altered total and differential leukocytes count. Additionally, PDTC caused a significant decrease in lung contents of hydroxyproline, TGF-?1, TNF-?, lipid peroxides, and total nitrite coupled with increase in lung GSH content as compared to bleomycin control group. Conclusion: PDTC attenuated bleomycin-induced pulmonary fibrosis in rats via its anti-inflammatory, antioxidant, and antifibrotic activities. � 2016 Taylor & Francis. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=18480&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.publisher | Taylor and Francis Ltd | en_US |
| dc.relation.ispartofseries | Experimental Lung Research | |
| dc.relation.ispartofseries | 42 | |
| dc.subject | bleomycin | en_US |
| dc.subject | nitric oxide | en_US |
| dc.subject | pulmonary fibrosis | en_US |
| dc.subject | pyrrolidinedithiocarbamate | en_US |
| dc.subject | tumor necrosis factor-alpha | en_US |
| dc.subject | bleomycin | en_US |
| dc.subject | collagen | en_US |
| dc.subject | glutathione | en_US |
| dc.subject | hydroxyproline | en_US |
| dc.subject | inducible nitric oxide synthase | en_US |
| dc.subject | lipid peroxide | en_US |
| dc.subject | malonaldehyde | en_US |
| dc.subject | nitrite | en_US |
| dc.subject | pyrrolidine dithiocarbamate | en_US |
| dc.subject | transforming growth factor beta1 | en_US |
| dc.subject | tumor necrosis factor | en_US |
| dc.subject | antiinflammatory agent | en_US |
| dc.subject | antioxidant | en_US |
| dc.subject | bleomycin | en_US |
| dc.subject | pyrrolidine derivative | en_US |
| dc.subject | pyrrolidine dithiocarbamic acid | en_US |
| dc.subject | thiocarbamic acid derivative | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | animal model | en_US |
| dc.subject | animal tissue | en_US |
| dc.subject | antifibrotic activity | en_US |
| dc.subject | antiinflammatory activity | en_US |
| dc.subject | antioxidant activity | en_US |
| dc.subject | Article | en_US |
| dc.subject | biochemical analysis | en_US |
| dc.subject | bleomycin-induced pulmonary fibrosis | en_US |
| dc.subject | bronchoalveolar lavage fluid | en_US |
| dc.subject | clinical evaluation | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | drug activity | en_US |
| dc.subject | drug efficacy | en_US |
| dc.subject | histopathology | en_US |
| dc.subject | immunohistochemistry | en_US |
| dc.subject | inflammation | en_US |
| dc.subject | leukocyte differential count | en_US |
| dc.subject | lipid peroxidation | en_US |
| dc.subject | lung injury | en_US |
| dc.subject | lung lavage | en_US |
| dc.subject | lung parenchyma | en_US |
| dc.subject | lung structure | en_US |
| dc.subject | male | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | oxidative stress | en_US |
| dc.subject | priority journal | en_US |
| dc.subject | protein expression | en_US |
| dc.subject | rat | en_US |
| dc.subject | animal | en_US |
| dc.subject | chemically induced | en_US |
| dc.subject | drug effects | en_US |
| dc.subject | inflammation | en_US |
| dc.subject | pathology | en_US |
| dc.subject | Pulmonary Fibrosis | en_US |
| dc.subject | Animals | en_US |
| dc.subject | Anti-Inflammatory Agents | en_US |
| dc.subject | Antioxidants | en_US |
| dc.subject | Bleomycin | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | Oxidative Stress | en_US |
| dc.subject | Pulmonary Fibrosis | en_US |
| dc.subject | Pyrrolidines | en_US |
| dc.subject | Rats | en_US |
| dc.subject | Thiocarbamates | en_US |
| dc.title | Pyrrolidinedithiocarbamate attenuates bleomycin-induced pulmonary fibrosis in rats: Modulation of oxidative stress, fibrosis, and inflammatory parameters | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1080/01902148.2016.1244578 | |
| dc.identifier.doi | PubMed ID 27797599 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
