Assessment of the link between endothelin K198n Snp, endothelin concentration and acute myocardial infarction in Egyptians
Abdel Rahman M.F.; Hashad I.M.; Abou-Aisha K.; Abdel Maksoud S.M.; Gad M.Z.
Date issued:
2017
Publisher:
Blackwell Publishing
Series Info:
Clinical and Experimental Pharmacology and Physiology
44
Type:
Letter
Keywords:
acute myocardial infarction
,
Egyptian
,
endothelin
,
polymorphism
,
endothelin
,
endothelin 1
,
endothelin 1
,
acute heart infarction
,
adult
,
controlled study
,
Egyptian
,
female
,
gene frequency
,
genotype
,
human
,
incidence
,
Letter
,
major clinical study
,
male
,
protein blood level
,
single nucleotide polymorphism
,
blood
,
Egypt
,
genetic linkage
,
genetics
,
middle aged
,
Myocardial Infarction
,
single nucleotide polymorphism
,
Adult
,
Egypt
,
Endothelin-1
,
Female
,
Genetic Linkage
,
Humans
,
Male
,
Middle Aged
,
Myocardial Infarction
,
Polymorphism, Single Nucleotide
Abstract:
The aim of the current study was to assess the link between EDN K198N SNP, ET-1 serum concentration and acute myocardial infarction (AMI) in Egyptians. The study cohort consisted of 84 patients at AMI onset and 84 age-matched healthy controls. Endothelin genotypes and concentrations were determined by sequencing and ELISA, respectively. Genotype distribution was not significantly different between AMI patients and controls (P=.8341). The mean serum ET-1 concentration of patients (13.83�0.7�pg/mL) was significantly higher than controls (7.26�0.2�pg/mL) (P<.0001). ET-1 serum concentrations did not vary significantly among various EDN genotypes in patients (P=.378) and controls (P=.6164). Hence, we conclude that EDN K198N genotypes were not related to either ET-1 concentration or incidence of early-onset AMI in Egyptians. But, AMI patients had higher ET-1 concentrations than controls. � 2016 John Wiley & Sons Australia, Ltd
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