Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on AlMo gel
JavaScript is disabled for your browser. Some features of this site may not work without it.
Preparation and biological profile of 99mTc-lidocaine as a cardioselective imaging agent using 99mTc eluted from 99Mo/99mTc generator based on AlMo gel
Series Info:Journal of Radioanalytical and Nuclear Chemistry 314
Type:Article
Keywords:October University for Modern Sciences and Arts
,
University for Modern Sciences and Arts
,
MSA University
,
جامعة أكتوبر للعلوم الحديثة والآداب
,
99Mo/99mTc generator
,
Heart imaging
,
Lidocaine
,
Myocardial perfusion
,
aluminum
,
lidocaine
,
molybdenum 99
,
molybdic acid
,
procainamide
,
technetium 99m
,
valsartan
,
animal experiment
,
animal tissue
,
Article
,
cardioselectivity
,
controlled study
,
elution
,
gel
,
isotope labeling
,
mouse
,
myocardial perfusion imaging
,
nonhuman
,
radioactivity
,
receptor affinity
,
structure analysis
Abstract:
The current study is aimed to prepare 99mTc-lidocaine as a new myocardial perfusion-imaging agent. The used 99mTc was obtained from Al. 99Mo-molybdate(VI) gel matrix. 99mTc-lidocaine showed higher (15.4. 0.11% ID/g) and faster (15. min post injection) cardiac uptake than the recently studied 99mTc-valsartan and 99mTc-procainamide. Consequently, 99mTc-lidocaine will be a valuable myocardial SPECT agent for diagnosis of emergency patients. Besides, the receptor affinity study confirmed the selectivity of 99mTc-lidocaine for sodium channels in the heart. 2017, Akadmiai Kiad, Budapest, Hungary.
