Brain Cortical and Hippocampal Dopamine: A New Mechanistic Approach for Eurycoma longifolia Well-Known Aphrodisiac Activity and Its Chemical Characterization
Ezzat, Shahira M; Ezzat M.I.; Okba M.M.; Hassan S.M.; Alkorashy A.I.; Karar M.M.; Ahmed S.H.; Mohamed S.O.; Fernandes G.
Date issued:
2019
Publisher:
Hindawi Limited
Series Info:
Evidence-based Complementary and Alternative Medicine
2019
Type:
Article
Keywords:
October University for Modern Sciences and Arts
,
University for Modern Sciences and Arts
,
MSA University
,
جامعة أكتوبر للعلوم الحديثة والآداب
,
dopamine
,
Eurycoma longifolia extract
,
follitropin
,
luteinizing hormone
,
noradrenalin
,
quassinoid derivative
,
serotonin
,
testosterone
,
aphrodisiac activity
,
Article
,
body weight
,
brain cortex
,
chemical composition
,
controlled study
,
drug activity
,
ejaculation
,
Eurycoma longifolia
,
female
,
follitropin blood level
,
hippocampus
,
ionization
,
latent period
,
LD50
,
luteinizing hormone blood level
,
male
,
mount latency
,
nonhuman
,
noradrenalin level
,
penis erection
,
prostate weight
,
rat
,
seminal vesicle
,
sexual behavior
,
Simaroubaceae
,
single drug dose
,
tandem mass spectrometry
,
testosterone blood level
,
ultra performance liquid chromatography
Abstract:
Eurycoma longifolia Jack (Fam.: Simaroubaceae), known as Tongkat Ali (TA), has been known as a symbol of virility and sexual power for men. Metabolic profiling of the aqueous extract of E. longifolia (AEEL) using UPLC-MS/MS in both positive and negative modes allowed the identification of seventeen metabolites. The identified compounds were classified into four groups: quassinoids, alkaloids, triterpenes, and biphenylneolignans. AEEL is considered safe with oral LD50 cut-off >5000 mg/kg. Oral administration of 50, 100, 200, 400, or 800 mg/kg of AEEL for 10 consecutive days to Sprague-Dawley male rats caused significant reductions in mounting, intromission, and ejaculation latencies and increased penile erection index. AEEL increased total body weight and relative weights of seminal vesicles and prostate. Total and free serum testosterone and brain cortical and hippocampal dopamine content was significantly elevated in treated groups with no significant effects on serotonin or noradrenaline content. 2019 Shahira M. Ezzat et al.
Description:
Scopus
MSA Google Scholar
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