Chemical and biological assessment of Tecoma x Smithii Hort.
Saleh N.A.; Ezzat, Shahira M; El-Kashoury E.-S.A.; Taha K.F.
Date issued:
2019
Publisher:
Wiley-Blackwell
,
Society of Pharmaceutical Sciences of Ankara (FABAD)
Series Info:
Fabad Journal of Pharmaceutical Sciences
44
Type:
Article
Keywords:
October University for Modern Sciences and Arts
,
University for Modern Sciences and Arts
,
MSA University
,
جامعة أكتوبر للعلوم الحديثة والآداب
,
Antidiabetic
,
Gallic acid
,
GC-MS
,
Nonacosane
,
Quercetin
,
Sitosterol
,
1 hexadecene
,
1 hexadecyne
,
1 nonadecene
,
1 octadecene
,
2 phenyl dodecane
,
2 phenyl tridecane
,
2 phenyl undecane
,
3 phenyl dodecane
,
3 phenyl tridecane
,
3 phenyl undecane
,
5 eicosene
,
5 phenyl tridecane
,
5 phenyl undecane
,
6 phenyl tridecane
,
6,10,14 trimethyl 2 pentadecanone
,
6,6 dimethyl cyclooct 4 enone
,
antidiabetic agent
,
antiinflammatory agent
,
antipyretic analgesic agent
,
cyclohexadecane
,
heptadecane
,
indometacin
,
metformin
,
neophytadiene
,
nonadecane
,
paracetamol
,
plant extract
,
stearic acid
,
tecoma x smithii hort extract
,
unclassified drug
,
unindexed drug
,
animal experiment
,
antidiabetic activity
,
antiinflammatory activity
,
Article
,
chemical analysis
,
comparative study
,
controlled study
,
drug determination
,
drug identification
,
drug potency
,
drug screening
,
flower
,
fruit
,
high performance liquid chromatography
,
limit of quantitation
,
mass fragmentography
,
nonhuman
,
plant leaf
,
quantitative analysis
,
rat
,
Tecoma
,
Tecoma x smithii hort
Abstract:
Spectrophotometric quantitative determination of polyphenols, flavonoids, alkaloids, sterols, and carbohydrates of the leaves, flowers and fruits of Tecoma x smithii Will. Wats. was performed, as well as the lipoidal matter (unsaponifiable compounds and fatty acids methyl esters) that were investigated using gas chromatography-mass spectrometry (GC-MS). Representative aromatic acids where estimated for the three parts using HPLC. Polyphenols and flavonoids were most concentrated in the 70% ethanol extract of the leaves. The investigation of the ethyl acetate fraction of the 70% ethanol extract of the leaves resulted in isolation and identification of Chrysoeriol (E1), Luteolin (E2), and Caffeic acid (E3). Two other compounds were also isolated from the n-butanol fraction: Chlorogenic acid (B1) and Rutin (B2). The ethanolic and aqueous extracts of the leaves were evaluated for their acute toxicity, anti-inflammatory, antipyretic, analgesic, and anti-hyperglycemic activities. Both extracts were regarded safe and could significantly reduce the blood glucose level in alloxan- diabetic rats and showed a comparable antipyretic and analgesic effect to the reference standards used in the study. � 2019 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
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