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| dc.contributor.author | Hassan D.S. | |
| dc.contributor.author | Hashad I.M. | |
| dc.contributor.author | Rahman M.F.A. | |
| dc.contributor.author | Abdel-Maksoud S.M. | |
| dc.contributor.other | Clinical Biochemistry Unit | |
| dc.contributor.other | Faculty of Pharmacy and Biotechnology | |
| dc.contributor.other | German University in Cairo | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Biochemistry Department | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Science and Arts | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:40:43Z | |
| dc.date.available | 2020-01-09T20:40:43Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 13892010 | |
| dc.identifier.other | https://doi.org/10.2174/1389201019666181031163748 | |
| dc.identifier.other | PubMed ID 30381070 | |
| dc.identifier.uri | https://t.ly/xRmwp | |
| dc.description | Scopus | |
| dc.description.abstract | Fractalkine (FKN) in its free and membrane bound-forms and its receptor CX3CR1are reported to have an atherosclerotic effect. The relationship of Single Nucleotide Polymorphisms (SNPs) in FKN and CX3CR1genes with the Coronary Artery Disease (CAD) risk showed conflicting results in different populations. The aim of this study was to investigate the influence of CX3CR1 threonine 280 methionine (T280M) polymorphism in the predisposition of Acute Coronary Syndrome (ACS) in Egyptians. Methods: 200 Egyptian subjects were recruited for the study. They were divided into 100 ACS patients and 100 healthy controls. Genotyping of CX3CR1 T280M was performed using a Polymerase Chain Reaction-restriction Fragment Length Polymorphism (PCR-RFLP). Serum FKN was assayed by Enzyme - Linked - Immuno- Sorbent-Assay (ELISA). Results: T and M allele frequencies for CX3CR1gene were not significantly different between ACS and Controls (p=0.76). Moreover, none of the genotypes had an atheroprotective effect. Serum analysis showed higher levels of FKN in ACS patients (p=0.041). FKN levels were not significantly different among genotypes of control and ACS groups (p=0.34) and (p=0.38) respectively. Conclusion: This study shows that CX3CR1 T280M polymorphism does not affect the incidence of ACS the Egyptian population. Moreover, none of the genotypes were associated with higher FKN levels. � 2018 Bentham Science Publishers. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=15581&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.publisher | Bentham Science Publishers B.V. | en_US |
| dc.relation.ispartofseries | Current Pharmaceutical Biotechnology | |
| dc.relation.ispartofseries | 19 | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | University for Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | University for Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | Acute coronary syndrome | en_US |
| dc.subject | CX3CR1 | en_US |
| dc.subject | Egyptians | en_US |
| dc.subject | Fractalkine receptor | en_US |
| dc.subject | Inflammation | en_US |
| dc.subject | T280M polymorphism | en_US |
| dc.subject | biochemical marker | en_US |
| dc.subject | chemokine receptor CX3CR1 | en_US |
| dc.subject | triacylglycerol | en_US |
| dc.subject | chemokine receptor CX3CR1 | en_US |
| dc.subject | CX3CL1 protein, human | en_US |
| dc.subject | CX3CR1 protein, human | en_US |
| dc.subject | fractalkine | en_US |
| dc.subject | acute coronary syndrome | en_US |
| dc.subject | adult | en_US |
| dc.subject | Article | en_US |
| dc.subject | autosomal dominant inheritance | en_US |
| dc.subject | autosomal recessive inheritance | en_US |
| dc.subject | cholesterol blood level | en_US |
| dc.subject | comparative study | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | coronary artery atherosclerosis | en_US |
| dc.subject | disease predisposition | en_US |
| dc.subject | Egyptian | en_US |
| dc.subject | enzyme linked immunosorbent assay | en_US |
| dc.subject | female | en_US |
| dc.subject | gene frequency | en_US |
| dc.subject | genetic association | en_US |
| dc.subject | genetic polymorphism | en_US |
| dc.subject | genetic variability | en_US |
| dc.subject | genotype | en_US |
| dc.subject | human | en_US |
| dc.subject | major clinical study | en_US |
| dc.subject | male | en_US |
| dc.subject | middle aged | en_US |
| dc.subject | non ST segment elevation myocardial infarction | en_US |
| dc.subject | pathogenesis | en_US |
| dc.subject | polymerase chain reaction | en_US |
| dc.subject | prevalence | en_US |
| dc.subject | restriction fragment length polymorphism | en_US |
| dc.subject | ST segment elevation myocardial infarction | en_US |
| dc.subject | unstable angina pectoris | en_US |
| dc.subject | acute coronary syndrome | en_US |
| dc.subject | Egypt | en_US |
| dc.subject | genetic predisposition | en_US |
| dc.subject | genetics | en_US |
| dc.subject | incidence | en_US |
| dc.subject | metabolism | en_US |
| dc.subject | single nucleotide polymorphism | en_US |
| dc.subject | Acute Coronary Syndrome | en_US |
| dc.subject | Chemokine CX3CL1 | en_US |
| dc.subject | CX3C Chemokine Receptor 1 | en_US |
| dc.subject | Egypt | en_US |
| dc.subject | Female | en_US |
| dc.subject | Gene Frequency | en_US |
| dc.subject | Genetic Predisposition to Disease | en_US |
| dc.subject | Genotype | en_US |
| dc.subject | Humans | en_US |
| dc.subject | Incidence | en_US |
| dc.subject | Male | en_US |
| dc.subject | Middle Aged | en_US |
| dc.subject | Polymorphism, Single Nucleotide | en_US |
| dc.title | The association of fractalkine receptor (T280m) polymorphism in the pathogenesis of acute coronary syndrome in the Egyptian population | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.2174/1389201019666181031163748 | |
| dc.identifier.doi | PubMed ID 30381070 | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
