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| dc.contributor.author | Hamed M.M. | |
| dc.contributor.author | Abd El-Mobdy M.A. | |
| dc.contributor.author | Kamel M.T. | |
| dc.contributor.author | Mohamed H.I. | |
| dc.contributor.author | Bayoumi A.E. | |
| dc.contributor.other | Medicinal Chemistry Department | |
| dc.contributor.other | Theodor Bilharz Research Institute | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt; Faculty of Biotechnology | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | Egypt; Biological and Geological Sciences Department | |
| dc.contributor.other | Faculty of Education | |
| dc.contributor.other | Ain Shams University | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:40:34Z | |
| dc.date.available | 2020-01-09T20:40:34Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 18278620 | |
| dc.identifier.uri | https://t.ly/pywKA | |
| dc.description | Scopus | |
| dc.description.abstract | Identifying ornamental plants as new natural anticancer sources is always of great effective for the ornamental and horticultural industries. The investigator for Senecio vulgaris were identified by GC-MS to give a total of 14 sesquiterpenoids, represents 98.53% of the total oil, while Pluchea dioscoridis L. shows the standardization of 30 compounds essential oil represents 91.28% of the total oil. Senecio vulgaris essential oil showed a high brine shrimp lethality with LC50 value of 8 ?g/ml followed by Pluchea dioscoridis L with LC50 value of 24 ?g/ml. Following cytotoxic activity was screened by MTT viability test against HePG2 cell line. Inhibitory activity against Hepatocellular carcinoma cells of S. vulgaris and P. dioscoridis L essential oil extract under the experimental conditions exhibited a promising IC50 of 5.63 and 11.50 �g/ml, respectively compared to Doxorubicin as a control. The results demonstrated the potential of the two plants essential oils for cancer treatments; therefore, in the future in vivo experiments are required for further understanding of the effect of these plants on cancer cells to be useful in medicine. � 2019, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved. | en_US |
| dc.language.iso | English | en_US |
| dc.publisher | SILAE (Italo-Latin American Society of Ethnomedicine) | en_US |
| dc.relation.ispartofseries | Pharmacologyonline | |
| dc.relation.ispartofseries | 2 | |
| dc.subject | Cytotoxic activity | en_US |
| dc.subject | Pluchea dioscoridis L | en_US |
| dc.subject | Senecio vulgaris | en_US |
| dc.subject | Volatile oil | en_US |
| dc.subject | doxorubicin | en_US |
| dc.subject | essential oil | en_US |
| dc.subject | plant extract | en_US |
| dc.subject | Pluchea dioscoridis extract | en_US |
| dc.subject | Senecio vulgaris extract | en_US |
| dc.subject | sesquiterpenoid | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | animal experiment | en_US |
| dc.subject | Artemia | en_US |
| dc.subject | Article | en_US |
| dc.subject | Asteraceae | en_US |
| dc.subject | biological activity | en_US |
| dc.subject | cell viability assay | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | cytotoxicity | en_US |
| dc.subject | drug identification | en_US |
| dc.subject | drug screening | en_US |
| dc.subject | drug structure | en_US |
| dc.subject | Hep-G2 cell line | en_US |
| dc.subject | human | en_US |
| dc.subject | human cell | en_US |
| dc.subject | IC50 | en_US |
| dc.subject | LC50 | en_US |
| dc.subject | lethality | en_US |
| dc.subject | mass fragmentography | en_US |
| dc.subject | MTT assay | en_US |
| dc.subject | nonhuman | en_US |
| dc.subject | phytochemistry | en_US |
| dc.subject | Pluchea dioscoridis | en_US |
| dc.subject | Senecio vulgaris | en_US |
| dc.subject | standardization | en_US |
| dc.title | Phytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L. | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
