Phytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L.

Hamed M.M.; Abd El-Mobdy M.A.; Kamel M.T.; Mohamed H.I.; Bayoumi A.E.

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Phytochemical and biological activities of two asteraceae plants senecio vulgaris and pluchea dioscoridis L.

Hamed M.M.; Abd El-Mobdy M.A.; Kamel M.T.; Mohamed H.I.; Bayoumi A.E.

Full Text link: https://t.ly/pywKA

Date issued: 2019

Publisher: SILAE (Italo-Latin American Society of Ethnomedicine)

Series Info: Pharmacologyonline
2

Type: Article

Keywords: Cytotoxic activity , Pluchea dioscoridis L , Senecio vulgaris , Volatile oil , doxorubicin , essential oil , plant extract , Pluchea dioscoridis extract , Senecio vulgaris extract , sesquiterpenoid , unclassified drug , animal experiment , Artemia , Article , Asteraceae , biological activity , cell viability assay , controlled study , cytotoxicity , drug identification , drug screening , drug structure , Hep-G2 cell line , human , human cell , IC50 , LC50 , lethality , mass fragmentography , MTT assay , nonhuman , phytochemistry , Pluchea dioscoridis , Senecio vulgaris , standardization

Abstract:

Identifying ornamental plants as new natural anticancer sources is always of great effective for the ornamental and horticultural industries. The investigator for Senecio vulgaris were identified by GC-MS to give a total of 14 sesquiterpenoids, represents 98.53% of the total oil, while Pluchea dioscoridis L. shows the standardization of 30 compounds essential oil represents 91.28% of the total oil. Senecio vulgaris essential oil showed a high brine shrimp lethality with LC50 value of 8 ?g/ml followed by Pluchea dioscoridis L with LC50 value of 24 ?g/ml. Following cytotoxic activity was screened by MTT viability test against HePG2 cell line. Inhibitory activity against Hepatocellular carcinoma cells of S. vulgaris and P. dioscoridis L essential oil extract under the experimental conditions exhibited a promising IC50 of 5.63 and 11.50 �g/ml, respectively compared to Doxorubicin as a control. The results demonstrated the potential of the two plants essential oils for cancer treatments; therefore, in the future in vivo experiments are required for further understanding of the effect of these plants on cancer cells to be useful in medicine. � 2019, SILAE (Italo-Latin American Society of Ethnomedicine). All rights reserved.