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| dc.contributor.author | El-Hawary S.S. | |
| dc.contributor.author | El-Hefnawy H.M. | |
| dc.contributor.author | Osman S.M. | |
| dc.contributor.author | Mostafa E.S. | |
| dc.contributor.author | Mokhtar F.A. | |
| dc.contributor.author | El-Raey M.A. | |
| dc.contributor.other | Department of Pharmacognosy | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt; Department of Pharmacognosy | |
| dc.contributor.other | Faculty of Pharmacy | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | 6thOctober City | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt; Phytochemistry and Plant Systematic Department | |
| dc.contributor.other | National Research Centre | |
| dc.contributor.other | Dokki | |
| dc.contributor.other | Cairo | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:40:31Z | |
| dc.date.available | 2020-01-09T20:40:31Z | |
| dc.date.issued | 2019 | |
| dc.identifier.issn | 9757058 | |
| dc.identifier.other | https://doi.org/10.22159/ijap.2019v11i6.33646 | |
| dc.identifier.other | PubMed ID : | |
| dc.identifier.uri | https://t.ly/LXvXg | |
| dc.description | Scopus | |
| dc.description.abstract | Objective: Evaluation of two Jasminum sambac L. (Ait) cultivars; Arabian Nights (JSA) and Grand Duke of Tuscany (JSG) ethanolic leaves extracts as reducing agents for the green synthesis of silver nanoparticles (AgNPs) and evaluation of their cytotoxicity against MCF-7 breast cancer and 5637 bladder cancer cell lines and chemical profiling of the two cultivars. Methods: The synthesis of silver nanoparticles (AgNPs) by the two cultivars and characterization of AgNPs by ultraviolet (UV)�visible spectroscopy, Transmission electron microscopy (TEM) and Fourier Transform Infrared Spectroscopy (FTIR). Additionally, the use of The high-performance liquid chromatography coupled with photodiode array-mass-mass-spectroscopy (HPLC-PDA-MS/MS) for chemical profiling of both cultivars and evaluation of total leaves extracts and corresponding nanoparticles towards MCF-7 and 5637 cell lines compared to aneuploidy immortal keratinocyte (Ha Cat) normal cells by neutral cell assay. Results: The green synthesized AgNPs (of an average size range of 8.83 and 11.24 nm for JSA and JSG, respectively) exhibited cytotoxicity against MCF-7 and 5637 cell lines. The IC50 was determined for each total extract JSA (15.29�2.16 ?g/ml) and JSG (20.28�1.20 ?g/ml) and corresponding AgNPs 17.32�2.22 ?g/ml and 6.32�1.01?g/ml for JSA and JSG, respectively. The IC50 of JSA and JSG against 5637 bladder cancer cell line were 13.76�1.11 ?g/ml and 50.69�3.75 ?g/ml, while the corresponding AgNPs showed IC50 of 5.54�0.88 ?g/ml and 27.89�2.84 ?g/ml, respectively. The HPLC-PDA-MS/MS allowed the identification of 59 compounds; 10 simple phenols, 17 flavonoids; quercetin and kaempferol glycosides, 2 lignans, and 30 secoiridoids; oleuropein, molihauside, and sambacoside. Conclusion: This study proved that JSA is an excellent source for the synthesis of AgNPs with optimum characters and enhanced activities toward MCF-7 and 5637 cell lines in correlation to identified compounds. � 2019 The Authors. | en_US |
| dc.description.uri | https://www.scimagojr.com/journalsearch.php?q=19900192174&tip=sid&clean=0 | |
| dc.language.iso | English | en_US |
| dc.publisher | Innovare Academics Sciences Pvt. Ltd | en_US |
| dc.relation.ispartofseries | International Journal of Applied Pharmaceutics | |
| dc.relation.ispartofseries | 11 | |
| dc.subject | University for Modern Sciences and Arts | |
| dc.subject | October University for Modern Sciences and Arts | |
| dc.subject | MSA University | |
| dc.subject | جامعة أكتوبر للعلوم الحديثة والآداب | |
| dc.subject | AgNPs | en_US |
| dc.subject | Cytotoxicity | en_US |
| dc.subject | Green synthesis | en_US |
| dc.subject | HPLC-PDA-MS/MS | en_US |
| dc.subject | Jasminum sambac | en_US |
| dc.subject | etoposide | en_US |
| dc.subject | Jasminum sambac extract | en_US |
| dc.subject | kaempferol | en_US |
| dc.subject | lignan | en_US |
| dc.subject | oleuropein | en_US |
| dc.subject | plant extract | en_US |
| dc.subject | protocatechualdehyde | en_US |
| dc.subject | quercetin | en_US |
| dc.subject | secoiridoid | en_US |
| dc.subject | silver nanoparticle | en_US |
| dc.subject | unclassified drug | en_US |
| dc.subject | vincristine | en_US |
| dc.subject | 5637 cell line | en_US |
| dc.subject | Article | en_US |
| dc.subject | bladder cancer | en_US |
| dc.subject | chemical fingerprinting | en_US |
| dc.subject | cytotoxicity | en_US |
| dc.subject | cytotoxicity assay | en_US |
| dc.subject | drug synthesis | en_US |
| dc.subject | drug therapeutic index | en_US |
| dc.subject | Egypt | en_US |
| dc.subject | Fourier transform infrared spectroscopy | en_US |
| dc.subject | high performance liquid chromatography | en_US |
| dc.subject | human | en_US |
| dc.subject | human cell | en_US |
| dc.subject | IC50 | en_US |
| dc.subject | jasmine | en_US |
| dc.subject | keratinocyte | en_US |
| dc.subject | MCF-7 cell line | en_US |
| dc.subject | species cultivation | en_US |
| dc.subject | transmission electron microscopy | en_US |
| dc.subject | ultraviolet visible spectroscopy | en_US |
| dc.title | Chemical profile of two jasminum sambac L. (AIT) cultivars cultivated in egypt-their mediated silver nanoparticles synthesis and selective cytotoxicity | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.22159/ijap.2019v11i6.33646 | |
| dc.identifier.doi | PubMed ID : | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
