Chemometric discrimination of three Pistacia species via their metabolic profiling and their possible in vitro effects on memory functions

El Bishbishy M.H.; Gad H.A.; Aborehab N.M.

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Chemometric discrimination of three Pistacia species via their metabolic profiling and their possible in vitro effects on memory functions

El Bishbishy M.H.; Gad H.A.; Aborehab N.M.

Full Text link: https://www.sciencedirect.com/science/article/pii/S0731708519306648

Date issued: 2020

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Doi: https://doi.org/10.1016/j.jpba.2019.112840 PubMed ID 31522096

Publisher: CIC Edizioni Internazionali s.r.l. , Elsevier B.V.

Series Info: Journal of Pharmaceutical and Biomedical Analysis
177

Type: Article

Keywords: October University for Modern Sciences and Arts , جامعة أكتوبر للعلوم الحديثة والآداب , University of Modern Sciences and Arts , MSA University , Anti-choline esterase , Anti-inflammatory activities , GC�MS , Pistacia , UHPLC-ESI-MS , anthocyanin , antiinflammatory agent , catechin , cholinesterase inhibitor , flavonoid , glycoside , isoquercitrin , kaempferol 3 o di hexose o pentose , kaempferol 3 o hexose o deoxy hexose o pentoside , kaempferol 3 o malonylhexoside , luteolin 7 o glycuronide , myricetin 3 o galactoside , myricetin galloyl hexoside , myricetin rutinoside , phenol derivative , Pistacia chinensis extract , Pistacia khinjuk extract , Pistacia lentiscus extract , plant extract , quercetin 3 o di hexose o pentose , quercetin 3 o glucuronide , quercetin 3 o hexose o pentoside , quercetin 3 o malonyl hexoside , quercetin 3,4 diglucoside , quercetin galloyl deoxyhexose , quercetin galloyl hexoside , quercetin galloyl hexuronide , quercetin glucoside o rutinoside , rutoside , unclassified drug , unindexed drug , antiinflammatory activity , Article , chemometric analysis , cholinesterase inhibition , controlled study , electrospray mass spectrometry , in vitro study , mass fragmentography , memory , metabolic fingerprinting , Pistacia , Pistacia chinensis , Pistacia khinjuk , Pistacia lentiscus , plant leaf , priority journal , ultra performance liquid chromatography

Abstract:

Alzheimer's disease (AD) is the most widespread neurodegenerative disease; there are around ten million new cases of Alzheimer yearly worldwide especially in middle or low-income countries. Pistacia is a genus of flowering plants including the well-known, economically important P. chinensis Bunge, P. lentiscus L. and P. khinjuk. In this study, the metabolic profiling of Pistacia leaves extracts was achieved via UHPLC-ESI-MS analysis and GC�MS analysis employing chemometric analysis for their discrimination. In addition, the methanolic extracts of different Pistacia species were assessed for their anti-cholinesterase and anti-inflammatory activities by various in vitro assays. 37 and 30 metabolites belonging to different classes were identified by UHPLC-ESI-MS and GC�MS analyses respectively. Chemometric analysis revealed that P. lentiscus and P. khinjuk were more closely related chemically to each other. All studied Pistacia leaves extracts showed apparent anti-cholinesterase and anti-inflammatory activities, which promotes their use in the prevention and management of AD. � 2019 Elsevier B.V.