Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

Huy, NT; Dibas, M; Hou, V; Low, SK; Tieu, TM; Hieu, TH; El Tanany, HHM; Abd El Hamid Hassan, HH; Kamel, MG; Abd-Elhay, FA; Elhusseiny, KM

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Examined and positive lymph nodes counts and lymph nodes ratio are associated with survival in major salivary gland cancer

Huy, NT; Dibas, M; Hou, V; Low, SK; Tieu, TM; Hieu, TH; El Tanany, HHM; Abd El Hamid Hassan, HH; Kamel, MG; Abd-Elhay, FA; Elhusseiny, KM

Full Text link: https://www.ncbi.nlm.nih.gov/pubmed/30905082

Date issued: 2019-08

Doi: https://doi.org/

Publisher: WILEY

Series Info: HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK;Volume: 41 Issue: 8 Pages: 2625-2635

Type: Article

Keywords: TUMORS , HEAD , RECTAL-CANCER , NODAL METASTASIS , SIGNIFICANT PREDICTOR , NECK-CANCER , DUCT CARCINOMA , BREAST-CANCER , SQUAMOUS-CELL CARCINOMA , INDEPENDENT PROGNOSTIC-FACTOR , survival , SEER , salivary gland , ratio , metastasis , lymph node

Abstract:

Background We aimed to investigate the prognostic role of examined (dissected) lymph nodes (ELNs), negative LNs (NLNs), and positive (metastatic) LNs (PLNs) counts and LN ratio (LNR = PLNs/ELNsx100) in patients with major salivary gland cancer (SGC). Methods Data were retrieved for major SGC patients diagnosed between 1988 and 2011 from Surveillance, Epidemiology, and End Results program. Results We have included 5446 patients with major SGC. Most patients had parotid gland cancer (84.61%). Patients having >18 ELNs, >4 PLNs, and >33.33% LNR were associated with a worse survival. Moreover, older age, male patients, grade IV, distant stage, unmarried patients, submandibular gland cancer, and received chemotherapy but not received surgery were significantly associated with a worse survival. Conclusions We demonstrated that patients with >18 ELNs and >4 PLNs counts, and >33.33% LNR were high-risk group patients. We strongly suggest adding the ELNs and PLNs counts and/or LNR into the current staging system.