Abstract:
We investigated the effects of cinnamic acid (CA, 20 mg/kg body weight) on
cisplatin (CP)-induced hepto and nephrotoxicity in mice. CP (5 mg/kg bwt) was
injected intraperitoneally and CA was given by gastric gavage for 5 days pre- and
post-CP injection. After 5 days of CP injection, CP-induced injuries of the hepatic
and renal tissues which were evidenced (i) histopathological damage of the hepatic
and renal tissues, (ii) as increases in liver and kidney function parameters, (iii) as
increases in lipid peroxidation and nitric oxide, and (iv) as decrease in glutathione
content. In contrast, the oral administration of CA concurrently to CP intoxicated
mice brought back lipid peroxidation, nitric oxide, glutathione levels to near
normalcy. Moreover, the histological observations evidenced that CA effectively
rescues the liver and kidney from CP mediated oxidative damage. Therefore,
cinnamic acid can be considered a potential candidate for protection of hepato-and
nephrotoxicity induced by cisplatin.
