Series Info:Microbial Biosystems;Volume: 3 Issue: 2 Pages: 46-55
Type:Article
Keywords:University of Anti-leukemic, enzymes, Saint Katherine Protectorate, gel filtration
Abstract:
Endophytic fungi produce important bioactive primary and secondary metabolites.
Researchers used L-Asparaginase for the treatment of Acute Lymphoblastic leukemia (ALL).
Endophytic taxon, Lasiodiplodia theobromae (Pat.) Griff. and Maubl. has been isolated from
Teucrium polium plant tissues collected from Saint Katherine Protectorate and was screened for
its ability to produce L-Asparaginase qualitatively and quantitatively. The crude enzyme has
been partially purified using gel-filtration Sephadex G-100 with an activity of 21.00 lMmL-1
min-1
. The results revealed that L. theobromae (SCUF-TP2016) represents a rich source of
bioactive metabolites that can be manipulated to produce L-Asparaginase which is a desirable
novel analog for chemotherapy.