dc.contributor.author |
taha Mohamed, Hossam |
|
dc.contributor.author |
Hesham Abdel Fattah, Hadeer |
|
dc.contributor.author |
El-Shinawi, Mohamed |
|
dc.contributor.author |
Abdelaziz Ibrahim, Sherif |
|
dc.contributor.author |
S. El-Halawany, Medhat |
|
dc.contributor.author |
El Ghazaly, Hesham |
|
dc.contributor.author |
Schneider, Robert |
|
dc.contributor.author |
Mohamed, Mona |
|
dc.date.accessioned |
2020-03-01T08:09:26Z |
|
dc.date.available |
2020-03-01T08:09:26Z |
|
dc.date.issued |
2017 |
|
dc.identifier.other |
https://doi.org/10.1200/jco.2015.33.15_suppl.e22238 |
|
dc.identifier.uri |
https://t.ly/rxyq0 |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
Background: Inflammatory breast cancer (IBC) is the most lethal form of breast cancer. Our previous results showed that IBC carcinoma tissues possess mixed human cytomegalovirus genotypes than non-IBC carcinoma tissues. However, the role of viral infection in breast cancer is poorly understood. Methods: We enrolled 135 women diagnosed breast cancer (91 Non-IBC and 44 IBC). The incidence of different viral DNA (Herpes viruses and HPV) was performed using nested and multiplex PCR and DNA sequencing. The expression of Ki-67 proliferation index was assessed by immunohistochemistry. Results: DNA of HCMV and HPV-16 were the most detected in breast tissues of both IBC and non-IBC patients. However, as a single infection the incidence of HCMV-DNA and HHV-8 DNA were significantly higher in carcinoma tissues of IBC in comparison with non-IBC (p = 0.035, p= 0.039, respectively). Moreover, the prevalence of mixed infection of different viral DNA was higher in IBC than non-IBC carcinoma tissues (P= 0.003). HCMV and HPV-16 were the dominant mixed infection in both non-IBC and IBC tissues. Interestingly, although no significant difference in expression of Ki67 has been detected in tissues of IBC and non-IBC, we found that Ki-67 was significantly higher in mixed than single viral infected tissues of both non-IBC and IBC (p = 0.04 and p = 0.03 respectively). Conclusions: The incidence of mixed viral DNA detected in carcinoma tissues of IBC is higher than non-IBC. Moreover, mixed viral DNA is positively correlated with upregulation of Ki67 expression in breast carcinoma tissues. |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
American Society of Clinical Oncology |
en_US |
dc.relation.ispartofseries |
Journal of Clinical Oncology;33, no. 15_suppl |
|
dc.subject |
Cancer Biology |
en_US |
dc.subject |
breast cancer |
en_US |
dc.title |
Inflammatory breast cancer: Mixed viral infections within carcinoma tissues and the expression of Ki-67 proliferation marker. |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1200/jco.2015.33.15_suppl.e22238 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|