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| dc.contributor.author | El-Shinawi, Mohamed | |
| dc.contributor.author | Taha Mohamed, Hossam | |
| dc.contributor.author | A. El-Ghonaimy, Eslam | |
| dc.contributor.author | Tantawy, Marwa | |
| dc.contributor.author | Younis, Amal | |
| dc.contributor.author | J. Schneider, Robert | |
| dc.contributor.author | Mostafa Mohamed, Mona | |
| dc.date.accessioned | 2020-02-29T08:18:52Z | |
| dc.date.available | 2020-02-29T08:18:52Z | |
| dc.date.issued | 2013 | |
| dc.identifier.citation | 1. Amarante MK, Watanabe MA (2009) The possible involvement of virus in breast cancer. J Cancer Res Clin Oncol 135: 329–337. [PubMed] [Google Scholar] 2. Zamora MR (2011) DNA viruses (CMV, EBV, and the herpesviruses). Semin Respir Crit Care Med 32: 454–470. [PubMed] [Google Scholar] 3. Niedobitek G, Meru N, Delecluse HJ (2001) Epstein-Barr virus infection and human malignancies. Int J Exp Pathol 82: 149–170. [PMC free article] [PubMed] [Google Scholar] 4. Fawzy S, Sallam M, Awad NM (2008) Detection of Epstein-Barr virus in breast carcinoma in Egyptian women. Clin Biochem 41: 486–492. [PubMed] [Google Scholar] 5. Hachana M, Amara K, Ziadi S, Romdhane E, Gacem RB, et al. (2011) Investigation of Epstein-Barr virus in breast carcinomas in Tunisia. Pathol Res Pract 207: 695–700. [PubMed] [Google Scholar] 6. Soroceanu L, Cobbs CS (2011) Is HCMV a tumor promoter? Virus Res 157: 193–203. [PMC free article] [PubMed] [Google Scholar] 7. Harkins L, Volk AL, Samanta M, Mikolaenko I, Britt WJ, et al. (2002) Specific localisation of human cytomegalovirus nucleic acids and proteins in human colorectal cancer. Lancet 360: 1557–1563. [PubMed] [Google Scholar] 8. Samanta M, Harkins L, Klemm K, Britt WJ, Cobbs CS (2003) High prevalence of human cytomegalovirus in prostatic intraepithelial neoplasia and prostatic carcinoma. J Urol 170: 998–1002. [PubMed] [Google Scholar] 9. Tsai JH, Hsu CS, Tsai CH, Su JM, Liu YT, et al. (2007) Relationship between viral factors, axillary lymph node status and survival in breast cancer. J Cancer Res Clin Oncol 133: 13–21. [PubMed] [Google Scholar] 10. Harkins LE, Matlaf LA, Soroceanu L, Klemm K, Britt WJ, et al. (2010) Detection of human cytomegalovirus in normal and neoplastic breast epithelium. Herpesviridae 1: 8. [PMC free article] [PubMed] [Google Scholar] 11. Melnick M, Sedghizadeh PP, Allen CM, Jaskoll T (2011) Human cytomegalovirus and mucoepidermoid carcinoma of salivary glands: Cell-specific localization of active viral and oncogenic signaling proteins is confirmatory of a causal relationship. Exp Mol Pathol 92: 118–125. [PubMed] [Google Scholar] 12. Cobbs CS (2011) Evolving evidence implicates cytomegalovirus as a promoter of malignant glioma pathogenesis. Herpesviridae 2: 10. [PMC free article] [PubMed] [Google Scholar] 13. Soroceanu L, Matlaf L, Bezrookove V, Harkins L, Martinez R, et al. (2011) Human cytomegalovirus US28 found in glioblastoma promotes an invasive and angiogenic phenotype. Cancer Res 71: 6643–6653. [PMC free article] [PubMed] [Google Scholar] 14. Baryawno N, Rahbar A, Wolmer-Solberg N, Taher C, Odeberg J, et al. (2011) Detection of human cytomegalovirus in medulloblastomas reveals a potential therapeutic target. J Clin Invest 121: 4043–4055. [PMC free article] [PubMed] [Google Scholar] 15. Cobbs CS, Harkins L, Samanta M, Gillespie GY, Bharara S, et al. (2002) Human cytomegalovirus infection and expression in human malignant glioma. Cancer Res 62: 3347–3350. [PubMed] [Google Scholar] 16. Maussang D, Verzijl D, van Walsum M, Leurs R, Holl J, et al. (2006) Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis. Proc Natl Acad Sci U S A 103: 13068–13073. [PMC free article] [PubMed] [Google Scholar] 17. Chan G, Bivins-Smith ER, Smith MS, Yurochko AD (2008) Transcriptome analysis of NF-kappaB- and phosphatidylinositol 3-kinase-regulated genes in human cytomegalovirus-infected monocytes. J Virol 82: 1040–1046. [PMC free article] [PubMed] [Google Scholar] 18. Chan G, Bivins-Smith ER, Smith MS, Yurochko AD (2009) NF-kappaB and phosphatidylinositol 3-kinase activity mediates the HCMV-induced atypical M1/M2 polarization of monocytes. Virus Res. [PMC free article] [PubMed] 19. Juckem LK, Boehme KW, Feire AL, Compton T (2008) Differential initiation of innate immune responses induced by human cytomegalovirus entry into fibroblast cells. J Immunol 180: 4965–4977. [PubMed] [Google Scholar] 20. Dumortier J, Streblow DN, Moses AV, Jacobs JM, Kreklywich CN, et al. (2008) Human cytomegalovirus secretome contains factors that induce angiogenesis and wound healing. J Virol 82: 6524–6535. [PMC free article] [PubMed] [Google Scholar] 21. Fiorentini S, Luganini A, Dell’Oste V, Lorusso B, Cervi E, et al. (2011) Human cytomegalovirus productively infects lymphatic endothelial cells and induces a secretome that promotes angiogenesis and lymphangiogenesis through interleukin-6 and granulocyte-macrophage colony-stimulating factor. J Gen Virol 92: 650–660. [PubMed] [Google Scholar] 22. Allart S, Martin H, Detraves C, Terrasson J, Caput D, et al. (2002) Human cytomegalovirus induces drug resistance and alteration of programmed cell death by accumulation of deltaN-p73alpha. J Biol Chem 277: 29063–29068. [PubMed] [Google Scholar] 23. Van Laere SJ, Van den Eynden GG, Van der Auwera I, Vandenberghe M, van Dam P, et al. (2006) Identification of cell-of-origin breast tumor subtypes in inflammatory breast cancer by gene expression profiling. Breast Cancer Res Treat 95: 243–255. [PubMed] [Google Scholar] 24. Labidi SI, Mrad K, Mezlini A, Ouarda MA, Combes JD, et al. (2008) Inflammatory breast cancer in Tunisia in the era of multimodality therapy. Ann Oncol 19: 473–480. [PubMed] [Google Scholar] 25. Lo AC, Georgopoulos A, Kleer CG, Banerjee M, Omar S, et al. (2009) Analysis of RhoC expression and lymphovascular emboli in inflammatory vs non-inflammatory breast cancers in Egyptian patients. Breast 18: 55–59. [PMC free article] [PubMed] [Google Scholar] 26. Soliman AS, Banerjee M, Lo AC, Ismail K, Hablas A, et al. (2009) High proportion of inflammatory breast cancer in the Population-based Cancer Registry of Gharbiah, Egypt. Breast J 15: 432–434. [PMC free article] [PubMed] [Google Scholar] 27. Duke TJ, Jahed NC, Veneroso CC, Da Roza R, Johnson O, et al. (2010) A cluster of inflammatory breast cancer (IBC) in an office setting: additional evidence of the importance of environmental factors in IBC etiology. Oncol Rep 24: 1277–1284. [PubMed] [Google Scholar] 28. Al-Raawi D, Abu-El-Zahab H, El-Shinawi M, Mohamed MM (2011) Membrane type-1 matrix metalloproteinase (MT1-MMP) correlates with the expression and activation of matrix metalloproteinase-2 (MMP-2) in inflammatory breast cancer. Int J Clin Exp Med 4: 265–275. [PMC free article] [PubMed] [Google Scholar] 29. Nouh MA, Mohamed MM, El-Shinawi M, Shaalan MA, Cavallo-Medved D, et al. (2011) Cathepsin B: a potential prognostic marker for inflammatory breast cancer. J Transl Med 9: 1. [PMC free article] [PubMed] [Google Scholar] 30. Zhang S, Zhou YH, Li L, Hu Y (2010) Monitoring human cytomegalovirus infection with nested PCR: comparison of positive rates in plasma and leukocytes and with quantitative PCR. Virol J 7: 73. [PMC free article] [PubMed] [Google Scholar] 31. Toi M, Ohashi Y, Seow A, Moriya T, Tse G, et al. (2010) The Breast Cancer Working Group presentation was divided into three sections: the epidemiology, pathology and treatment of breast cancer. Jpn J Clin Oncol 40 Suppl 1i13–18. [PubMed] [Google Scholar] 32. Bonnier P, Charpin C, Lejeune C, Romain S, Tubiana N, et al. (1995) Inflammatory carcinomas of the breast: a clinical, pathological, or a clinical and pathological definition? Int J Cancer 62: 382–385. [PubMed] [Google Scholar] 33. Gong Y (2008) Pathologic aspects of inflammatory breast cancer: part 2. Biologic insights into its aggressive phenotype. Semin Oncol 35: 33–40. [PubMed] [Google Scholar] 34. Richardson AK, Cox B, McCredie MR, Dite GS, Chang JH, et al. (2004) Cytomegalovirus, Epstein-Barr virus and risk of breast cancer before age 40 years: a case-control study. Br J Cancer 90: 2149–2152. [PMC free article] [PubMed] [Google Scholar] 35. Retiere C, Imbert BM, David G, Courcoux P, Hallet MM (1998) A polymorphism in the major immediate-early gene delineates groups among cytomegalovirus clinical isolates. Virus Res 57: 43–51. [PubMed] [Google Scholar] 36. Sowmya P, Madhavan HN (2009) Analysis of mixed infections by multiple genotypes of human cytomegalovirus in immunocompromised patients. J Med Virol 81: 861–869. [PubMed] [Google Scholar] 37. Van Laere S, Van der Auwera I, Van den Eynden GG, Fox SB, Bianchi F, et al. (2005) Distinct molecular signature of inflammatory breast cancer by cDNA microarray analysis. Breast Cancer Res Treat 93: 237–246. [PubMed] [Google Scholar] 38. Van Laere SJ, Van der Auwera I, Van den Eynden GG, Elst HJ, Weyler J, et al. (2006) Nuclear factor-kappaB signature of inflammatory breast cancer by cDNA microarray validated by quantitative real-time reverse transcription-PCR, immunohistochemistry, and nuclear factor-kappaB DNA-binding. Clin Cancer Res 12: 3249–3256. [PubMed] [Google Scholar] 39. Lerebours F, Vacher S, Andrieu C, Espie M, Marty M, et al. (2008) NF-kappa B genes have a major role in inflammatory breast cancer. BMC Cancer 8: 41. [PMC free article] [PubMed] [Google Scholar] 40. Yurochko AD, Kowalik TF, Huong SM, Huang ES (1995) Human cytomegalovirus upregulates NF-kappa B activity by transactivating the NF-kappa B p105/p50 and p65 promoters. J Virol 69: 5391–5400. [PMC free article] [PubMed] [Google Scholar] 41. Smith MS, Bivins-Smith ER, Tilley AM, Bentz GL, Chan G, et al. (2007) Roles of phosphatidylinositol 3-kinase and NF-kappaB in human cytomegalovirus-mediated monocyte diapedesis and adhesion: strategy for viral persistence. J Virol 81: 7683–7694. [PMC free article] [PubMed] [Google Scholar] 42. Michaelis M, Doerr HW, Cinatl J (2009) The story of human cytomegalovirus and cancer: increasing evidence and open questions. Neoplasia 11: 1–9. [PMC free article] [PubMed] [Google Scholar] 43. Soderberg-Naucler C (2008) HCMV microinfections in inflammatory diseases and cancer. J Clin Virol 41: 218–223. [PubMed] [Google Scholar] 44. Fagundes CP, Glaser R, Alfano CM, Bennett JM, Povoski SP, et al... (2011) Fatigue and herpesvirus latency in women newly diagnosed with breast cancer. Brain Behav Immun. [PMC free article] [PubMed] 45. Breathnach O, Donnellan P, Collins D, McNicholas W, Crown J (1999) Cytomegalovirus pneumonia in a patient with breast cancer on chemotherapy: case report and review of the literature. Ann Oncol 10: 461–465. [PubMed] [Google Scholar] 46. Chang S, Parker SL, Pham T, Buzdar AU, Hursting SD (1998) Inflammatory breast carcinoma incidence and survival: the surveillance, epidemiology, and end results program of the National Cancer Institute, 1975–1992. Cancer 82: 2366–2372. [PubMed] [Google Scholar] 47. Cheeran MC, Hu S, Yager SL, Gekker G, Peterson PK, et al. (2001) Cytomegalovirus induces cytokine and chemokine production differentially in microglia and astrocytes: antiviral implications. J Neurovirol 7: 135–147. [PubMed] [Google Scholar] 48. Zhang Y, Wang YL, Liu YW, Li Q, Yuan YH, et al. (2009) Change of peripheral blood mononuclear cells IFN-gamma, IL-10, and TGF-beta1 mRNA expression levels with active human cytomegalovirus infection in orthotopic liver transplantation. Transplant Proc 41: 1767–1769. [PubMed] [Google Scholar] 49. Shimamura M, Murphy-Ullrich JE, Britt WJ (2010) Human cytomegalovirus induces TGF-beta1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition. PLoS Pathog 6: e1001170. [PMC free article] [PubMed] [Google Scholar] 50. Blaheta RA, Beecken WD, Engl T, Jonas D, Oppermann E, et al. (2004) Human cytomegalovirus infection of tumor cells downregulates NCAM (CD56): a novel mechanism for virus-induced tumor invasiveness. Neoplasia 6: 323–331. [PMC free article] [PubMed] [Google Scholar] 51. Blaheta RA, Weich E, Marian D, Bereiter-Hahn J, Jones J, et al. (2006) Human cytomegalovirus infection alters PC3 prostate carcinoma cell adhesion to endothelial cells and extracellular matrix. Neoplasia 8: 807–816. [PMC free article] [PubMed] [Google Scholar] 52. Cinatl J Jr, Cinatl J, Vogel JU, Kotchetkov R, Driever PH, et al. (1998) Persistent human cytomegalovirus infection induces drug resistance and alteration of programmed cell death in human neuroblastoma cells. Cancer Res 58: 367–372. [PubMed] [Google Scholar] 53. Robertson FM, Bondy M, Yang W, Yamauchi H, Wiggins S, et al. (2010) Inflammatory breast cancer: the disease, the biology, the treatment. CA Cancer J Clin 60: 351–375. [PubMed] [Google Scholar] 54. Vermeulen PB, van Golen KL, Dirix LY (2010) Angiogenesis, lymphangiogenesis, growth pattern, and tumor emboli in inflammatory breast cancer: a review of the current knowledge. Cancer 116: 2748–2754. [PubMed] [Google Scholar] 55. Soderberg-Naucler C, Johnsen JI (2012) Cytomegalovirus infection in brain tumors: A potential new target for therapy? Oncoimmunology 1: 739–740. | en_US |
| dc.identifier.uri | https://t.ly/R0qOZ | |
| dc.description | MSA Google Scholar | en_US |
| dc.description.abstract | Human Cytomegalovirus (HCMV) is an endemic herpes virus that re-emerges in cancer patients enhancing oncogenic potential. Recent studies have shown that HCMV infection is associated with certain types of cancer morbidity such as glioblastoma. Although HCMV has been detected in breast cancer tissues, its role, if any, in the etiology of specific forms of breast cancer has not been investigated. In the present study we investigated the presence of HCMV infection in inflammatory breast cancer (IBC), a rapidly progressing form of breast cancer characterized by specific molecular signature. We screened for anti-CMV IgG antibodies in peripheral blood of 49 non-IBC invasive ductal carcinoma (IDC) and 28 IBC patients. In addition, we screened for HCMV-DNA in postsurgical cancer and non-cancer breast tissues of non-IBC and IBC patients. We also tested whether HCMV infection can modulate the expression and activation of transcriptional factor NF-κB/p65, a hallmark of IBC. Our results reveal that IBC patients are characterized by a statistically significant increase in HCMV IgG antibody titers compared to non-IBC patients. HCMV-DNA was significantly detected in cancer tissues than in the adjacent non-carcinoma tissues of IBC and IDC, and IBC cancer tissues were significantly more infected with HCMV-DNA compared to IDC. Further, HCMV sequence analysis detected different HCMV strains in IBC patients tissues, but not in the IDC specimens. Moreover, HCMV-infected IBC cancer tissues were found to be enhanced in NF-κB/p65 signaling compared to non-IBC patients. The present results demonstrated a correlation between HCMV infection and IBC. Etiology and causality of HCMV infection with IBC now needs to be rigorously examined. | en_US |
| dc.description.sponsorship | Public Library of Science | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Public Library of Science | en_US |
| dc.relation.ispartofseries | PloS one;Volume: 8 Issue: 2 | |
| dc.subject | University of Human cytomegalovirus infection | en_US |
| dc.subject | Breast Cancer Patients | en_US |
| dc.title | Human cytomegalovirus infection enhances NF-κB/p65 signaling in inflammatory breast cancer patients | en_US |
| dc.type | Article | en_US |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
