dc.contributor.author |
Maher Zahran, Eman |
|
dc.contributor.author |
Ramadan Abdelmohsen, Usama |
|
dc.contributor.author |
M Shalash, Mahmoud |
|
dc.contributor.author |
Ezzat Khalil, Hany |
|
dc.contributor.author |
. Alaraby Salem, M |
|
dc.date.accessioned |
2020-02-11T09:00:09Z |
|
dc.date.available |
2020-02-11T09:00:09Z |
|
dc.date.issued |
2019 |
|
dc.identifier.other |
https://doi.org/10.1080/14786419.2020.1719489 |
|
dc.identifier.uri |
https://cutt.ly/VrHzqfW |
|
dc.description |
MSA Google Scholar |
en_US |
dc.description.abstract |
The present study aimed to detect the bioactive metabolites from Ocimum forskolei aerial parts which are responsible for the local anaesthetic activity of the ethyl acetate fraction. Following a bioassay-guided fractionation, twelve compounds were dereplicated from the ethyl acetate fraction which was the most potent one with a mean onset of action (1.43 ± 0.07****) min compared to tetracaine as a positive control (1.37 ± 0.07****) min. These compounds, along with seven other compounds (isolated by diverse chromatographic techniques) were subjected to a molecular docking study to declare the top scoring compounds predicted to be responsible for such activity. The results highlighted Rabdosiin and Apigenin-7-O-rutinoside as the main bioactive leaders of the local anaesthesia via forming multiple H- bonding with the sodium ion channels leading to their blockade and loss of pain sensation, which strongly supports the use of O. forskolei as a local anaesthetic agent |
en_US |
dc.description.sponsorship |
Taylor and Francis |
en_US |
dc.language.iso |
en |
en_US |
dc.publisher |
Taylor and Francis |
en_US |
dc.relation.ispartofseries |
Journal Natural Product Research; |
|
dc.subject |
anaesthetic potential |
en_US |
dc.subject |
metabolic |
en_US |
dc.title |
Local anaesthetic potential, metabolic profiling, molecular docking and in silico ADME studies of Ocimum forskolei, family Lamiaceae |
en_US |
dc.type |
Article |
en_US |
dc.identifier.doi |
https://doi.org/10.1080/14786419.2020.1719489 |
|
dc.Affiliation |
October University for modern sciences and Arts (MSA) |
|