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| dc.contributor.author | ABOUSHOUSHA, TAREK | |
| dc.contributor.author | ATEF GHALY, CHRISTINA | |
| dc.contributor.author | GALAL, MOHAMED | |
| dc.contributor.author | KAMEL, AMIRA | |
| dc.date.accessioned | 2020-02-09T10:07:47Z | |
| dc.date.available | 2020-02-09T10:07:47Z | |
| dc.date.issued | 2018 | |
| dc.identifier.citation | Dahesh, SMA, Farid, BE, 2016: Epidemiological situation of urinary schistosomiasis in Tamwah Area, Giza, Egypt: assessment and control. J. Egypt. Soc. Parasitol. 46, 3:485-96. Dkhil, MA, Bauomy,AA, Diab, MSM, AlQuraishy, S, 2015:Antioxidant and hepatoprotective role of gold nanoparticles against murine hepatic schistosomiasis. Inter. J, Nanomed. 10: 7467-75. Baumann, CL, Aspalter, IM, Sharif, O, Pichlmair, A, et al, 2010: CD14 is a coreceptor of Toll-like receptors 7 and 9. J. Exp. Med. 207: 2689-701 Cavalcanti, M, Araujo-Neto, J, Peralta, J, 2015: Schistosomiasis: Clinical Management of Liver Disease, J. Clin. Liver Dis. 6:59-62 Chevillard, C, Eboumbou, C, Nasr-Eldin, M A, Bream, E, et al, 2003: IFN-_ Polymorphisms (IFN-2109 & IFN-3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni). J. Immunol. 171:5596-601. Herbert, DR, Holscher, C, Mohrs M, Arendse, B, et al, 2004: Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20:623-35. Han, D, She, W, Zhang, L, 2010: Association of CD14 gene polymorphism C-159T with allergic rhinitis. Am. J. Rhinol. Allergy 24, 1:e1-3. Jarvelainen, HA, Orpana, A, Perola, M, Savolainen, VT, et al, 2001: Promoter polymorphism of the CD14 endotoxin receptor gene as a risk factor for alcoholic liver disease, J. Hepatol. 33, 11:48-53. Kishore, R, Hill, JR, McMullen, M, Frenkel, J, 2002: Nagy LE. ERK1/2 and Egr-1 contribute to increased TNF-α production in rat Kupffer cells after chronic ethanol feeding ,Am. J. Physiol. 282:G6-15. Kono, H, Wheeler, MD, Rusyn, I, Lin, M, et al, 2000: Gender differences in early alcoholinduced liver injury: role of CD14, NF-kappaB, and TNF-alpha. Am. J. Physiol. 278:G652-61 Lee, HK, Dunzendorfer, S, Soldau, K, Tobias, PS, 2006: Double-stranded RNA-mediated TL R3 activation is enhanced by CD14. Immunity 24:153-63. Liaskou, E, Zimmermann, HW, Li, KK, Oo, YH, 2013: Monocyte subsets in human liver diseases how distinct phenotypic and functional characteristics. Hepatology 57, 1:38-42 Layland, LE, Rad, R, Wagner, H, da Costa, C U, 2007: Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2. Eur. J. Immunol. 37:2174-84. Michael, D, Wheeler, Ronald, G, Thurman, A, 2003: Up-regulation of CD14 in liver caused by acute ethanol involves oxidant-dependent AP-1 pathway, J. Biol. Chemis. 278:8435-41 Ogawa, Y, Imajo, K, Yoneda, M, Kessoku, T, et al, 2013: Soluble CD14 levels reflect liver inflammation in patients with nonalcoholic steatohepatitis. J. Plosone. 19:e65211. Pearce, EJ, MK, C, Sun, J, McKee, AS, et al, 2004: Th2 response polarization during infection with the helminth parasite Schistosoma mamsoni. Immunol. Rev. 201:117-26. Pearce, EJ, MacDonald, AS, 2002: The immunobiology of schistosomiasis. Nat. Rev. Immunol. 2:499-51 Sackesen, C, Birben, E, Soyer, OU, Sahiner, UM, et al, 2011: The effect of CD14 C159T polymorphism on in vitro IgE synthesis and cytokine production by PBMC from children with asthma. J. Allergy 66:48-57. Tang, C, Liu, Z, Gao, Y, Xiong, F, 2018: Schistosoma infection and Schistosoma-derived products modulate the immune responses associated with protection against type 2 Diabetes. J. Frontiers 8:1990 Tundup, S, Srivastava, L, Nagy, T, Harna, D, 2014: CD14 influences host immune responses and alternative activation of macrophages during Schistosoma mansoni infection. JASM 3:240-51. Vanhoutte, F, Breuilh, L, Fontaine, J, Zouain, CS, et al, 2007: Toll-likereceptor (TLR)2 and TLR3 sensing is required for dendritic cell acti- 317 vation, but dispensable to control Schistosoma mansoni infection and pathology. J. Microbes Infect. 9:1606-13. Yin, M, Bradford, BU, Wheeler, MD, Uesugi, T, et al, 2001: Reduced early alcohol-induced liver injury in CD14-deficient mice. J. Immunol. 166:4737-42 Zang, M, Li, Y, He, H, Ding, H, et al, 2018: IL-23 production of liver inflammatory macrophages to damaged hepatocytes promotes hepatocellular carcinoma development after chronic hepatitis B virus infection. Biochim. Biophys. Acta. Mol. Basis Dis. 1864, 12:3759-70. Zaiss, MM, Rapin, A, Lebon, L, Dubey, LK, et al, 2015: The intestinal microbiota contributes to the ability of helminths to modulate allergic inflammation. J. Immunity 43, 5:998-1010. | en_US |
| dc.identifier.uri | https://t.ly/ZyvKe | |
| dc.description | MSA Google Scholar | en_US |
| dc.description.abstract | Bilharziasis is one of the most common parasitic diseases, mostly affecting the liver by causing the formation of granuloma and hepatic fibrosis, and historically endemic diseases in Egypt. Hundreds of studies examined the hepatic schistosomiasis pathogenesis to find out points for possible drug interference with disease progression and complications. The macrophages are the major source of CD14 in liver granulomas of S. mansoni-infected mice and CD14 might have regulatory roles during infection. The current study evaluated the cellular expression of CD14 in livers of S. mansoni infected mice in comparison with healthy controls, for assessment of its potential regulatory role in schistosome-induced hepatic fibrosis. Histopathological study of livers of S. mansoni infected mice after 12 weeks of infection was conducted using routine H&E stain and M.T stain for tissue fibrosis. Immunohistochemical evaluation of CD14 positive cells was also performed using DAB as a chromogen. The results showed upregulation of CD14 expression in infected mice, compared to healthy control mice, with variable percentage and different distribution in relation to granuloma type. | en_US |
| dc.description.sponsorship | Journal of the Egyptian Society of Parasitology | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Journal of the Egyptian Society of Parasitology | en_US |
| dc.relation.ispartofseries | J. Egypt. Soc. Parasitol. (JESP);Volume: 48 Issue: 3 Pages: 713-719 | |
| dc.subject | University of Egypt, CD14, Schistosomiasis mansoni, Liver, Immunohistochemistry, EMT | en_US |
| dc.title | IMMUNOHISTOPATHOLOGICAL EVALUATION OF HEPATIC CD14 EXPRESSION IN MURINE SCHISTOSOMIASIS MANSONI | en_US |
| dc.type | Article | en_US |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
