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| dc.contributor.author | Abdelmajed S.S. | |
| dc.contributor.author | Youssef M. | |
| dc.contributor.author | Zaki M.E. | |
| dc.contributor.author | Abu-Mandil Hassan N. | |
| dc.contributor.author | Ismail S. | |
| dc.contributor.other | October University for Modern Sciences and Arts (MSA) | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt; Organic chemistry Department | |
| dc.contributor.other | Faculty of science | |
| dc.contributor.other | Cairo University | |
| dc.contributor.other | Egypt; Biological Anthropology Department | |
| dc.contributor.other | Medical Research Division | |
| dc.contributor.other | National Research Centre | |
| dc.contributor.other | Egypt; Medical Molecular Genetics Department | |
| dc.contributor.other | Human Genetics and Genome Research Division | |
| dc.contributor.other | National Research Centre | |
| dc.contributor.other | Giza | |
| dc.contributor.other | Egypt | |
| dc.date.accessioned | 2020-01-09T20:41:19Z | |
| dc.date.available | 2020-01-09T20:41:19Z | |
| dc.date.issued | 2017 | |
| dc.identifier.issn | 23523042 | |
| dc.identifier.other | https://doi.org/10.1016/j.gendis.2017.06.002 | |
| dc.identifier.other | PubMedID | |
| dc.identifier.uri | https://t.ly/mbbjg | |
| dc.description | Scopus | |
| dc.description.abstract | Obesity is a common disorder that has a significant impact on human health as it may lead to many serious diseases and sometimes morbidity. Previous genome-wide association studies (GWAS) confirmed that there is a relationship between some variants in the first intron of the fat mass and obesity associated (FTO) gene and obesity in adults and children in different ethnic groups. In our study, the association of the FTO rs9939609 and rs17817449 variants with obesity was investigated in Egyptian children and adolescents. We examined rs9939609 and rs17817449 polymorphisms in 100 control and 100 obese cases, we used the restriction fragment length polymorphism (RFLP) technique to genotype the samples. The current study showed that there were no significant differences (P > 0.05) between the cases and controls in both variants of rs17817449 and rs9939609 polymorphisms. However, there were significant correlations between rs17817449 and cholesterol and between rs9939609 and LDL. In Current Study although the two variants (rs9939609 and rs17817449) didn't show an association with obesity, but there was a correlation between the lipid profile and these two variants. � 2017 Chongqing Medical University | en_US |
| dc.language.iso | English | en_US |
| dc.publisher | Chongqing yi ke da xue, di 2 lin chuang xue yuan Bing du xing gan yan yan jiu suo | en_US |
| dc.relation.ispartofseries | Genes and Diseases | |
| dc.relation.ispartofseries | 4 | |
| dc.subject | Children | en_US |
| dc.subject | Egyptians | en_US |
| dc.subject | Fat mass and obesity associated gene (FTO) | en_US |
| dc.subject | Obesity | en_US |
| dc.subject | Variants | en_US |
| dc.subject | alpha ketoglutarate dependent dioxygenase FTO | en_US |
| dc.subject | cholesterol | en_US |
| dc.subject | genomic DNA | en_US |
| dc.subject | high density lipoprotein cholesterol | en_US |
| dc.subject | low density lipoprotein cholesterol | en_US |
| dc.subject | triacylglycerol | en_US |
| dc.subject | adolescent | en_US |
| dc.subject | adolescent obesity | en_US |
| dc.subject | Article | en_US |
| dc.subject | body mass | en_US |
| dc.subject | case control study | en_US |
| dc.subject | child | en_US |
| dc.subject | childhood obesity | en_US |
| dc.subject | cholesterol blood level | en_US |
| dc.subject | controlled study | en_US |
| dc.subject | Egyptian | en_US |
| dc.subject | ethnic difference | en_US |
| dc.subject | gene frequency | en_US |
| dc.subject | genetic association | en_US |
| dc.subject | genetic risk | en_US |
| dc.subject | genotype | en_US |
| dc.subject | hip circumference | en_US |
| dc.subject | human | en_US |
| dc.subject | major clinical study | en_US |
| dc.subject | molecular pathology | en_US |
| dc.subject | restriction fragment length polymorphism | en_US |
| dc.subject | single nucleotide polymorphism | en_US |
| dc.subject | total cholesterol level | en_US |
| dc.subject | triacylglycerol blood level | en_US |
| dc.subject | waist circumference | en_US |
| dc.subject | waist hip ratio | en_US |
| dc.title | Association analysis of FTO gene polymorphisms and obesity risk among Egyptian children and adolescents | en_US |
| dc.type | Article | en_US |
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| dcterms.source | Scopus | |
| dc.identifier.doi | https://doi.org/10.1016/j.gendis.2017.06.002 | |
| dc.identifier.doi | PubMedID | |
| dc.Affiliation | October University for modern sciences and Arts (MSA) |
