Abstract:
Hepatocellular carcinoma is defined as a tumor of the liver and is classified as the
primary liver cancer as it is a malignant tumor composed of hepatocytes cells. It's one of
the most common malignancies in adults, and is extra common in men than women.
Overall, the mortality rate was 1,000,000 deaths within year. The majority of HCC
appears to be caused by cirrhosis from chronic hepatitis B and hepatitis C virus.
Therefore, the aim of this study is diagnosis of hepatocellular carcinoma as significance
correlation to platelet, alpha-fetoprotein and liver enzyme function tests as bilirubin,
GGT, ALT and AST to 128 patients in egyption population by using automated ELISA
technique for screening blood tests, hematology analyzer for counting platelet and
automated kinetic detection of liver enzyme function tests. The results of 128 patient
samples were divided to normal patients result 36 (28%) and abnormal patients result of
HCC 92 (72%) of total 128 samples. Data recorded from various liver diagnostic tests
had revealed that low platelet count were 68 (53%) while normal platelet count 60 (47%)
and high AFP were 79 (62%) while normal AFP 49 (38%) and high AST 56 (44%) while
normal AST 72 (56%) and high ALT were 57 (45%) while normal ALT 71 (55%) and
high GGT 67 (52%) while normal GGT 61 (48%) and high bilirubin 34 (37%) while
normal bilirubin 58 (63%).To conclude, blood screening tests as AFP is not an accurate
indication for HCC. Several cases could be suffering from hepatocellular carcinoma but
their AFP is within normal range. So, the most accurate way to diagnose and detect the
hepatocellular carcinoma is by using imaging techniques as triphasic computed
tomography abdomen and dynamic magnetic resonance imaging.
