Browsing Faculty of Biotechnology Research Paper by Author "Hafez, Mohamed M"

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Investigation of novel benzimidazole-based indole/thiazole hybrids derivatives as effective anti-diabetics and anti-alzheimer’s agents: Structure-activity relationship insight, in vitro and in silico approaches

Naz, Haseena; Othman, Mohamed S; Rahim, Fazal; Hussain, Rafaqat; Khan, Shoaib; Taha, Muhammad; Hafez, Mohamed M; Abdel-Hafez, Lina JM; Ullah, Hayat; Khan, Ihsan Ullah; Khan, Yousaf; Shah, Syed Adnan Ali (Elsevier B.V., 2024-05)

Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are common in developed countries and their incidence is increasing. The research is mostly concentrated on the exploration of novel therapies to remedy or ...
New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study

Othman, Mohamed s; Hayat, Shawkat; Rahim, Fazal; Taha, Muhammad; Sajid, Muhammad; Khan, Shoaib; Iqbal, Wajeeha; Shah, Syed Adnan Ali; Fareid, Mohamed A; Aboelnaga, Shimaa M; Abdel-Hafez, Lina JM; Hafez, Mohamed M (Elsevier, 2024-03)

In search of potent anti-Alzheimer agent benzimidazole based Schiff base derivatives (1–18) were synthesized and evaluated as dual inhibitor for acetylcholinesterase and butyrylcholinesterase enzymes. All analogs among the ...

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