Abstract:
Background: The intensive care unit is a special setting in hospitals where patients with
severe, life-threating conditions are admitted, these patients mostly suffer from serious
infections among other conditions which increases the mortality, morbidity and cost of
hospitalization. The presented study was conducted to assess the drug utilization pattern mostly
concerning the antibiotics prescription in the ICU. Aim is to Assess the treatment outcome
specially for different combined therapies used for the treatment of gram-negative bacterial
infections in the ICU and degree of improvement and period of staying in the ICU. Materials
and Methods Retrospective study conducted in Intensive Care Unit of Al-Moalmeen Hospital.
Analysis conducted on 54 cases admitted to ICU in six months. The data included: Age,
Diagnosis, Vital signs, Treatment plan, and the outcome. APACHE Score was used to measure
disease severity. Inclusion criteria: Patients with gram-negative bacteria infection from sputum,
blood, and urine cultures. Exclusion criteria: Patients with Glasgow coma scale less than 9,
End-stage metastatic malignant cancer patients, patients with APACHE II score more than 34,
ventilated patients upon admission. The data analyzed by performing statistics on “Graph Pad
Prism”. Results: Total 54 cases showed 62-gram negative bacteria cultures; 9 blood, 28 urine
and 15 sputum cultures, also 10 swabs. These 62-cultures showed 31 cases E-coli, 14 cases
klebsiella, 11 pseudomonas, and 6 cases Acinetobacter. 40 out 62 microorganisms treated with
monotherapy including (Meronem/Forutm/Maixpime/Rocephin/Tazocin). 22 out 62
microorganisms treated with combined therapy including (Meropenem/Tavanic,
Meronem/Ciprofloxacin, Meronem/Tigacylcine, Maxipime / Tavanic, Colistin/Gentamycin,
and Ciprofloxacin /Amikin). Treatment with antibiotics monotherapy and combined therapy,
empirical and targeted antibiotics therapy and Meronem antibiotic monotherapy and combined
therapy didn’t show significant differences regarding mortality and survival rates.
