Abstract:
Chemotherapy targets rapidly dividing tissues in the body. It destroys the progenitor cells
in gonads resulting in ovarian dysfunction. Studies have suggested that bone marrow-
derived stem cells can regenerate oocytes in chemotherapy-treated female rats after
transplantation. The present study aimed to assess mechanism of homing, the action of
injected BM-MSCs and orally administered taurine on ovarian function after ovarian
damage. Experimental design: Fifty female albino rats were randomly allocated into
Control, CTX group, The Experimental protocol lasted for 10 weeks during which serum
E2 and plasma serum ALT and MDA were monitored. Stem cells identification and
homing were evaluated by Flowcytometry. Also, histopathological examination was done
to evaluate both degeneration and regeneration of ovarian tissue. Principal observations:
Paclitaxel group indicated noticeable ovarian distress. Partial improvement of E2, ALT and
MDA levels as well as ovarian architecture. H&E staining showed that there were more
healthy ovarian follicles after treatment with BM-MSCs and Taurine. Conclusion: Our
results demonstrated that injected BM-MSCs can home in the stroma of the injured ovaries
and alongside the supplementation of Taurine, injured ovarian function could be restored.
