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Browsing by Author "Zaafan, Mai A"

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Dasatinib ameliorates thioacetamide-induced liver fibrosis: modulation of miR-378 and miR-17 and their linked Wnt/b-catenin and TGF-b/smads pathways

Zaafan, Mai A; Abdelhamid, Amr M (Taylor and Francis, 11/12/2021)

Hepatic stellate cells activation (HSCs) plays a crucial role in the pathogenesis of liver fibrosis. Specific microRNAs have been suggested to affect the activation of HSCs via various signalling pathways including TGF-b/smads ...
The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-β/Smads Pathways

Abdelhamid, Amr M; Selim, Ayman; Zaafan, Mai A (Frontiers Media S.A., 29/10/2021)

Liver fibrosis is characterized by a series of events including activation of quiescent hepatic stellate cells (HSCs) into proinflammatory, contractile, and fibrogenic myofibroblasts, which is the primary trigger for the ...
The impact of lncRNA-GAS5/miRNA-200/ACE2 molecular pathway on the severity of COVID-19

Ayeldeen, Ghada; Shaker, Olfat G; Amer, Eman; Zaafan, Mai A; Herzalla, Mohamed R; Keshk, Mofida A; Abdelhamid, Amr M (Bentham Science Publishers B.V., 2023-05)

was reported to be overexpressed and its targeted ACE2 was down-regulated. The ROC curve was drawn to examine the diagnostic abilities of GAS5, miR-200, and ACE2, yielding high diagnostic accuracy with high sensitivity and ...
Modulation of the miR-122/Sirt-6/ACE2 axis on experimentally-induced myocardial infarction

Abdel-Nasser, Zeinab M; Zaafan, Mai A; Abdelhamid, Amr M (Elsevier Ireland Ltd, 2022-11)

Myocardial infarction (MI) is a progressive myocardial necrosis that can lead to a number of life- threatening complications. MiRNAs have a crucial role in the pathogenesis of many cardiovascular diseases. Remarkably, ...
The pulmonary protective potential of vanillic acid-loaded TPGS-liposomes: modulation of miR-217/MAPK/NF-κb signalling pathway

Sweed, Nabila M; Zaafan, Mai A; El-Bishbishy, Mahitab H; Dawoud, Marwa H.S (Taylor and Francis Ltd, 2024-04)

The aim is to investigate the possible pulmonary protective effect of vanillic acid (VA) in liposome-TPGS nanoparticles, to overcome VA’s poor bioavailability. VA was successfully extracted. Liposomes were prepared using ...
Simvastatin ameliorates testosterone-induced prostatic hyperplasia in rats via modulating IGF-1/PI3K/AKT/FOXO signaling

El-Shafei, Nyera H; Zaafan, Mai A; Kandil, Esraa A; Sayed, Rabab H (Elsevier, 2023-05)

Benign prostatic hyperplasia (BPH) is characterized by non-malignant enlargement of prostate cells causing many lower urinary tract symptoms. BPH pathogenesis includes androgens receptors signaling pathways, oxidative ...

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Browsing by Author "Zaafan, Mai A"

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