Browsing by Author "P.O. Box 114"

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New approaches for the uses of cyclohexan-1,4-dione for the synthesis of 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-b]pyridine derivatives used as potential anti-prostate cancer agents and pim-1 Kinase inhibitors

Mohareb R.M.; Abdo N.Y.M.; El-Sharkawy K.A. (Bentham Science Publishers B.V., 2018)

Background: Among the wide range of heterocycles, tetrahydrobenzothienopyridine derivatives acquired a special attention due to their wide range of pharmacological activities especially the therapeutic activities. Many ...
Synthesis and antitumor activity of some novel thiophene, pyrimidine, coumarin, pyrazole and pyridine derivatives

Albratty M.; El-Sharkawy K.A.; Alam S. (Croatian Pharmaceutical Society, 2017)

2-Cyano-N-(thiazol-2-yl) acetamide (2a) and 2-cyano-N-(oxazol- 2-yl) acetamide (2b) were obtained via the reaction of ethyl cyanoacetate with either 2-aminothiazole (1a) or 2-aminooxazole (1b). The formed products were ...
Synthesis and evaluation of some new 1,3,4-oxadiazoles bearing thiophene, thiazole, coumarin, pyridine and pyridazine derivatives as antiviral agents

Albratty M.; El-Sharkawy K.A.; Alhazmi H.A. (Sciendo, 2019)

In an attempt to produce heterocyclic compounds based on 1,3,4-oxadiazole derivatives with potential antiviral activity, synthesis of compound 1 [2-(5-thioxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)acetonitrile] was performed ...

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