Abdel-Halim, Mohammad; Sigler, Sara; Racheed, Nora A. S; Hefnawy, Amr; Fathalla, Reem K; Hammam, Mennatallah A; Maher, Ahmed; Maxuitenko, Yulia; Keeton, Adam B; Hartmann, Rolf W; Engel, Matthias; Piazza, Gary A; Abadi, Ashraf H
(ACS Publications, 04/03/2021)
A ligand-based approach involving systematic
modifications of a trisubstituted pyrazoline scaffold derived from
the COX2 inhibitor, celecoxib, was used to develop novel PDE5
inhibitors. Novel pyrazolines were identified ...