Novel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activity

Mohareb R.M.Fleita D.H.Sakka O.K.Department of Organic ChemistryFaculty of PharmacyOctober University for Modern Sciences and ArtsOctober CityAREgypt; Department of ChemistryFaculty of ScienceCairo UniversityGizaAREgypt; Department of ChemistryFaculty of ScienceAmerican University in Cairo5th SettlementAREgypt2020-01-252020-01-25201114203049https://doi.org/10.3390/molecules16010016PubMed ID 21187814https://t.ly/ge8P2ScopusThe reaction of cyanoacetyl hydrazine (1) with 3-acetylpyridine (2) gave the hydrazide-hydrazone derivative 3. The latter compound undergoes a series of heterocyclization reactions to give new heterocyclic compounds. The antitumor evaluation of the newly synthesized products against three cancer cell lines, namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) was performed. Most of the synthesized compounds showed high inhibitory effects. � 2010 by the authors.English3-acetylpyridineAntitumor activityCoumarinHydrazide-hydrazoneThiopheneantineoplastic agentazidecoumarincoumarin derivativehydrazone derivativepyridinepyridine derivativethiazole derivativethiophene derivativearticlecell divisionchemistrydrug effectdrug screeninghumannuclear magnetic resonance spectroscopytumor cell lineAntineoplastic AgentsAzidesCell DivisionCell Line, TumorCoumarinsDrug Screening Assays, AntitumorHumansHydrazonesMagnetic Resonance SpectroscopyPyridinesThiazolesThiophenesNovel synthesis of hydrazide-hydrazone derivatives and their utilization in the synthesis of coumarin, pyridine, thiazole and thiophene derivatives with antitumor activityArticlehttps://doi.org/10.3390/molecules16010016PubMed ID 21187814