Salehi B.Ezzat, Shahira MTsouh Fokou P.V.Albayrak S.Vlaisavljevic S.Sharifi-Rad M.Bhatt I.D.Sharifi-Rad M.Belwal T.Ayatollahi S.A.Kobarfard F.Ata A.Baghalpour N.Martorell M.Setzer W.N.Sharifi-Rad J.Student Research CommitteeSchool of MedicineBam University of Medical SciencesBamIran; Pharmacognosy DepartmentFaculty of PharmacyCairo UniversityKasr El-Ainy StreetCairo11562Egypt; Department of PharmacognosyFaculty of PharmacyOctober University for Modern Science and Arts (MSA)12566Egypt; Department of BiochemistryFaculty of ScienceUniversity of Yaounde 1Po.Box 812YaoundeCameroon; Department of BiologyScience FacultyErciyes UniversityKayseri38039Turkey; Department of ChemistryBiochemistry and Environmental ProtectionFaculty of SciencesUniversity of Novi SadTrg Dositeja Obradovica 3Novi Sad21000Serbia; Department of Range and Watershed ManagementFaculty of Natural ResourcesUniversity of ZabolZabolIran; G.B. Pant National Institute of Himalayan Environment and Sustainable DevelopmentKosi-KatarmalAlmora263643India; Department of Medical ParasitologyZabol University of Medical SciencesZabolIran; Phytochemistry Research CenterShahid Beheshti University of Medical SciencesTehranIran; Department of ChemistryRichardson College for the Environmental Science ComplexThe University of Winnipeg599 Portage AvenueWinnipegMB R3B 2G3Canada; Department of Medicinal ChemistrySchool of PharmacyShahid Beheshti University of Medical SciencesTehran11369Iran; Department of Nutrition and DieteticsFaculty of PharmacyUniversity of ConcepcionConcepcionChile; Department of ChemistryUniversity of Alabama in HuntsvilleHuntsvilleAL 35899United States; Food Safety Research Center (salt)Semnan University of Medical SciencesSemnanIran2020-01-092020-01-09201922254110https://doi.org/10.1016/j.jtcme.2018.09.001PubMed ID :https://t.ly/9LJEYScopusMSA Google ScholarAthyrium plants consist of more than 230 species that are largely distributed in the Sino-Himalayan region and the Western Pacific islands. Athyrium species are being used in traditional medicine worldwide to treat various ailments such as cough, rheumatic pain, scorpion stings, sores, burns and scalds, intestinal fever, pain, specifically breast pain during child birth, to increase milk flow, as an antiparasitic, anthelmintic, and carminative. A deep look in the literature has revealed that Athyrium species have been poorly investigated for their food preservative applications and in vivo and in vitro biological and phytochemical studies. However, some Athyrium species have demonstrated antimicrobial, anti-inflammatory, antioxidant, antiproliferative and anti-HIV potential. Athyrium multidentatum (Doll.) Ching is the most investigated species and the biological activities of their extracts, such as they antioxidant properties, seem to be related to the sulfate contents of their polysaccharides. This review provides an update on the ethnopharmacology, phytochemistry and biological properties of Athyrium plants that might be useful for further research. Of course, well-designed clinical trials will be required for some species to be used as therapy. � 2018 Center for Food and Biomolecules, National Taiwan UniversityEnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA UniversitySoftware engineeringAdopting agileAthyriumBiological activitiesEthnobotanyEthnopharmacologyPhytoconstituentsReviewhttps://doi.org/10.1016/j.jtcme.2018.09.001PubMed ID :