Marmouzi I.Ezzat, Shahira MSalama M.M.Merghany R.M.Attar A.M.El-Desoky A.M.Mohamed S.O.University Mohammed v in RabatFacult� de M�dicine et PharmacieLaboratoire de Pharmacologie et Toxicologie�quipe de Pharmacocin�tiqueRabatMorocco; Pharmacognosy DepartmentFaculty of PharmacyCairo UniversityKasr El-Ainy StreetCairo11562Egypt; Department of PharmacognosyFaculty of PharmacyOctober University for Modern Sciences and Arts (MSA)6th October12611Egypt; Department of Pharmacognosy and Medicinal PlantsFaculty of PharmacyBritish University in EgyptCairo11837Egypt; Department of PharmacognosyNational Research CentreGizaEgypt; Faculty of Science and TechniquesHassan II University of CasablancaMohammediaMorocco; Department of Molecular BiologyGenetic Engineering and Biotechnology Research Institute (GEBRI)University of Sadat City (USC)Sadat CityEgypt; Natural Wellness Scientific OfficeKuala LumpurMalaysia2020-01-092020-01-09201923146133https://doi.org/10.1155/2019/4568039PubMed ID 31781615https://t.ly/2dw29ScopusMSA Google ScholarChemical structures derived from marine foods are highly diverse and pharmacologically promising. In particular, chitooligosaccharides (COS) present a safe pharmacokinetic profile and a great source of new bioactive polymers. This review describes the antioxidant, anti-inflammatory, and antidiabetic properties of COS from recent publications. Thus, COS constitute an effective agent against oxidative stress, cellular damage, and inflammatory pathogenesis. The mechanisms of action and targeted therapeutic pathways of COS are summarized and discussed. COS may act as antioxidants via their radical scavenging activity and by decreasing oxidative stress markers. The mechanism of COS antidiabetic effect is characterized by an acceleration of pancreatic islets proliferation, an increase in insulin secretion and sensitivity, a reduction of postprandial glucose, and an improvement of glucose uptake. COS upregulate the GLUT2 and inhibit digestive enzyme and glucose transporters. Furthermore, they resulted in reduction of gluconeogenesis and promotion of glucose conversion. On the other hand, the COS decrease inflammatory mediators, suppress the activation of NF-B, increase the phosphorylation of kinase, and stimulate the proliferation of lymphocytes. Overall, this review brings evidence from experimental data about protective effect of COS. � 2019 Ilias Marmouzi et al.EnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA Universitychitooligosaccharideoligosaccharideunclassified drugantidiabetic activityantiinflammatory activityantioxidant activitydrug activityhumannonhumanReviewReviewhttps://doi.org/10.1155/2019/4568039PubMed ID 31781615