Motawi, Tarek M. K.Mahdy, Soliman G.El-Sawalhi, Maha M.Ali, Eman N.El-Telbany, Rania Farag A.2019-11-182019-11-1820180008-4212https://doi.org/10.1139/cjpp-2017-0272https://www.nrcresearchpress.com/doi/abs/10.1139/cjpp-2017-0272Accession Number: WOS:000419166500006Cardiovascular diseases (CVD) are the leading cause of death in the diabetic population. Obesity is a serious problem that has been linked with CVD and diabetes via a variety of adipokines. The aims of this study were to evaluate and correlate circulating chemerin, apelin, vaspin, and omentin-1 levels in obese type 2 diabetic Egyptian patients with coronary artery stenosis (CAS), and to assess their usefulness as noninvasive diagnostic biomarkers. Chemerin, apelin, vaspin, and omentin-1 levels were determined by enzyme immunoassay in coronary artery disease (CAD) I patients (45 non-obese, nondiabetic with CAS), CAD II patients (45 obese, diabetic with CAS), and 30 controls. Patients in CAD I and CAD II groups exhibited higher levels of chemerin and apelin together with lower levels of vaspin and omentin-1 than in controls. These alterations were more significant in CAD II than in CAD I patients. Additionally, adipokine levels were individually correlated with each other and with certain biochemical variables. Moreover, chemerin and vaspin levels could differentiate CAD II patients from CAD I and controls. Alterations of these adipokines may play a crucial role in the pathogenesis of CAS in obese type 2 diabetic Egyptian patients. Chemerin and vaspin could be used as markers to support diagnosis of CAS.enUniversity of ChemerinApelinVaspinomentin-1ObesityT2DMCoronary stenosisC-REACTIVE PROTEINArticlehttps://doi.org/10.1139/cjpp-2017-0272