Mohareb R.M.Elmegeed G.A.Abdel-Salam O.M.E.Doss S.H.William M.G.Organic Chemistry DepartmentFaculty of PharmacyOctober University of Modern Sciences and Arts (MSA)Elwahaat RoadOctober CityEgypt; Chemistry DepartmentFaculty of ScienceCairo UniversityCarioEgypt; Hormones DepartmentNational Research Centre12622 DokkiCairoEgypt; Toxicology and Narcotics DepartmentNational Research Centre12622 DokkiCairoEgypt2020-01-252020-01-2520110039128Xhttps://doi.org/10.1016/j.steroids.2011.05.011PubMed ID 21664368https://t.ly/q2RA9ScopusThe identification of compounds able to treat both pain and inflammation with limited side effects is one of the prominent goals in biomedical research. This study aimed at the synthesis of new modified steroids with structures justifying non-ulcerogenic, anti-inflammatory and anti-nociceptive activities. The steroid derivatives were synthesized via straightforward and efficient methods and their structures were established based on the analytical and spectral data. The in vivo anti-inflammatory, anti-nociceptive and anti-ulcerogenic activities of some of these compounds were studied. The newly synthesized compounds 8b, 19b, 24 and 31a showed anti-inflammatory, anti-nociceptive and anti-ulcerogenic activity with various intensities. Oedema was significantly reduced by either dose 25 or 50 mg/kg of all tested compounds at 3 and 4 h post-carrageenan. Compound 19b was the most effective in alleviating thermal pain. The analgesic activity of either dose of the compounds 8b, 24, 31a as well as the high dose 19b was significantly higher than that for indomethacin (IND). Gastric mucosal lesions caused in the rats by the administration of 96% EtOH and IND were inhibited by all tested compounds administered at (50 mg/kg) dose in the study. � 2011 Elsevier Inc. All rights reserved.EnglishAnti-inflammatoryAnti-nociceptiveAnti-ulcerogenicAzolesEpoxidsOxarine17 (3' benzoyl 2' methyloxiran 2' yl)androst 4 ene 3 one17 (4',5' dihydro 3' hydroxy 5' methyl 4' phenylamino 1' phenylpyrazol 5' yl)androst 4 ene 3 one17 [4',5' dihydro 3',5' dimethyl 4' (4 chlorophenylamino) 1' phenylpyrazol 5' yl]androst 4 ene 3 one20 hydroxy 20 [1',3', 4' triphenyl 2' thioxo 1',3' imidazol 5' yl]pregn 4 ene 3 onecarrageenanindometacinsteroidtramadolunclassified druganimal experimentanimal modelantiinflammatory activityantinociceptionantiulcerogenic activityarticlecontrolled studydrug activitydrug efficacyin vivo studynonhumanpainpaw edemaratsteroidogenesisstomach lesionstomach ulcerstructure activity relationthermal painAcetic AcidAnalgesicsAnimalsAnti-Inflammatory AgentsAzolesCarrageenanEdemaMicePainRatsSteroidsRattusArticlehttps://doi.org/10.1016/j.steroids.2011.05.011PubMed ID 21664368