Eissa T.F.Gonzalez-Burgos E.Emilia Carretero M.Gomez-Serranillos M.P.Department of PharmacologyFaculty of PharmacyUniversity Complutense of MadridSpain; Pharmacognosy DepartmentFaculty of PharmacyOctober University of Modern Science and Arts (MSA)GizaEgypt2020-01-092020-01-0920181252526https://doi.org/https://t.ly/epwMnScopusAchillea fragrantissima (Forssk.) Sch. Bip. is one of the most popular and important medicinal plants extensively used in Egyptian folk medicine for healing different sufferings and diseases. The antioxidant properties of hydroalcoholic extract obtained from the aerial parts of A. fragrantissima were in vitro studied. The total phenolic content was 56.6 mg gallic acid equivalents/g dry weight, and the oxygen radical absorbance capacity (ORAC) was 1.127 ?mol Trolox equivalents/mg sample. The HPLC-MS identification of polyphenols revealed mainly the presence of flavones, in addition to benzoic acids, cinnamic acids, and flavonols. The hydroalcoholic extract protected human astrocytoma U373-MG cells against hydrogen peroxide-induced formation of reactive oxygen species and loss of cell viability. These findings suggest that the hydroalcoholic extract from A. fragrantissima is a natural source of antioxidant compounds that may be useful for counteracting the oxidative stress damage in central nervous system cells. � 2018, Chiang Mai University. All rights reserved.EnglishOctober University for Modern Sciences and ArtsUniversity for Modern Sciences and ArtsOctober University for Modern Sciences and ArtsMSA Universityجامعة أكتوبر للعلوم الحديثة والآدابAchillea fragrantissimaAntioxidant propertiesPolyphenolsArticlehttps://doi.org/