Mohamed, Yara Ahmed Hassaneen, H. M El‑Dessouky, Mohamed ASafwat, Gehan Hassan, Naglaa Abu‑Mandil Amr, Khalda 2021-07-252021-07-257/21/2021https://doi.org/10.1007/s11033-021-06560-1https://qrgo.page.link/7dxWTA cluster of many risk factors for type 2 diabetes and cardiovascular disease is used to describe the metabolic syndrome (MetS). Moreover, genetic differences associated with metabolic syndrome play a key role in its prevalence and side effects. This study aims to investigate the expression of DYRK1B and its association with metabolic syndrome in a small cohort of Egyptian. Materials and methods A total of 100 adult Egyptians (50 with MetS and 50 healthy control subjects) were included to this study. Clinical, biochemical and anthropometric analysis were assessed. Relative gene expressions of DYRK1B were compared between two groups of subjects using real time PCR. Results We observed marked overexpression in DYRK1B (p < 0.05) in MetS subjects when compared with the healthy control subjects. Conclusion This is the first study to provide evidence that DYRK1B is highly expressed among the MetS subjects.en-USMetabolic syndrome Gene expression DYRK1B Real Time PCRArticlehttps://doi.org/10.1007/s11033-021-06560-1