Mohareb, Rafat M.El-Sharkawy, Karam A.Sherif, Sherif M.2019-12-282019-12-282008Cited References in Web of Science Core Collection: 211330-0075https://doi.org/10.2478/v10007-008-0030-3https://www.ncbi.nlm.nih.gov/pubmed/19103577Accession Number: WOS:000262205800006Condensation of beta-amino-alpha,gamma-dicyanocrotononitrile (1) with acetophenone gave 2-amino-4-phenylpenta-1,3-diene-1,1,3-tricarbonitrile (2). The latter product was used in a series of heterocyclization reactions with different reagents such as diazonium salts, hydrazines, hydroxylamines and elemental sulfur to give pyridazine, pyrazole, isoxazole and thiophene derivatives, respectively. On the other hand, it gave pyridine derivatives with aromatic aldehydes folowed by reaction with cyanomethylene reagents. The MIC values for the newly synthesized product were measured against E. coli, B. cereus, B. subtilis and C. albicans.enUniversity of pyridine; isoxazole; pyridazine; thiophene; antimicrobial activityMOLLUSCICIDAL ACTIVITY; ANTITUMOR AGENTS; INHIBITORS; DISCOVERY; ANALOGS; POTENT; ACID; RINGArticlehttps://doi.org/10.2478/v10007-008-0030-3