Zaghloul S.S.Azzam S.M.Eid H.H.Hassan H.A.Sleem A.A.Pharmacognosy DepartmentCairo UniversityCairoEgypt; Pharmacognosy DepartmentOctober University for Modern Sciences and Arts (MSA)GizaEgypt; Pharmacology DepartmentNational Research CenterGizaEgypt2020-01-092020-01-0920159754873https://doi.org/https://t.ly/mbe7AScopusHydrodistilled essential oil of fresh leaves of Oroxylum indicum L. family Bignoniaceae cultivated in Egypt was analyzed by gas chromatography?mass spectrometry (GC/MS) .The yield of essential oil was (0.2 %) . Thirty nine components were identified representing (89.85%). Ar-tumerone (19.37%), a sesquiterpene ketone, was the major constituent in the oil followed by methyl hexadecanoate (6.2%), laurenan-2-one (5.59%) and isopropyl butanoate (5.57%). The oxygenated constituents represents (63.81 %) while non- oxygenated constituents represents (26.04 %) .The oil showed significant cytotoxic activity on MCF7 (breast carcinoma cell line), HEPG2 (liver carcinoma cell line) and HELA (cervix carcinoma cell line) ,in addition to good in vivo and in vitro antioxidant activity. The oil also exhibited both hepatoprotective and heptocurative action, but showed weak antimicrobial activity against tested bacteria with no effect against fungi. � 2015, International Journal of Pharmacognosy and Phytochemical Research. All rights reserved.EnglishAntioxidantCytotoxicEssential oilHepatoprotective and hepatocurative activityOroxylum indicum Lalanine aminotransferasealkaline phosphatasealpha tocopherolamphotericin Bascorbic acidaspartate aminotransferaseessential oilsilymarintetracyclineadultalanine aminotransferase blood levelalkaline phosphatase blood levelalloxan-induced diabetes mellitusanimal experimentanimal modelantimicrobial activityantineoplastic activityantioxidant activityArticleaspartate aminotransferase blood levelAspergillus nigerBacillus subtilisbreast carcinomaCandida albicansconcentration (parameters)concentration responsecontrolled studycytotoxicityDPPH radical scavenging assaydrug activityEgyptEscherichia coliHeLa cell linehepatocurative activityHepG2 cell linehydrodistillationin vitro studyin vivo studyliver cell carcinomaliver protectionmalemass fragmentographyMCF 7 cell linenonhumanOroxylumoxygenationphytochemistryplant leafPseudomonas aeruginosaratStaphylococcus aureusuterine cervix carcinomaArticlehttps://doi.org/