El Newahie A.M.S.Ismail N.S.M.Abou El Ella D.A.Abouzid K.A.M.Faculty of PharmacyDepartment of Pharmaceutical Organic ChemistryOctober University for Modern Science and Arts (MSA)CairoEgypt; Faculty of Pharmaceutical Sciences and Pharmaceutical IndustriesDepartment of Pharmaceutical ChemistryFuture UniversityCairoEgypt; Faculty of PharmacyDepartment of Pharmaceutical ChemistryAin Shams UniversityAbbassiaCairo11566Egypt2020-01-092020-01-0920163656233https://doi.org/10.1002/ardp.201500468PubMed ID 27062086https://t.ly/6xwGPScopusMSA Google ScholarQuinoxaline derivatives, also called benzopyrazines, are an important class of heterocyclic compounds. Quinoxalines have drawn great attention due to their wide spectrum of biological activities. They are considered as an important basis for anticancer drugs due to their potential activity as protein kinase inhibitors. In this review, we focus on the chemistry of the quinoxaline derivatives, the strategies for their synthesis, their potential activities against various tyrosine kinases, and on the structure-activity relationship studies reported to date. � 2016 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.EnglishAnticancerKinase inhibitorsQuinoxalinesSARSynthetic strategiesantineoplastic agentcyclin dependent kinase 1cyclin dependent kinase 2cyclin dependent kinase 4cyclin dependent kinase 6doxorubicinJanus kinase 2 inhibitorprotein kinase inhibitorprotein tyrosine kinase inhibitorquinoxaline derivativevasculotropin inhibitorantineoplastic agentprotein kinase inhibitorprotein tyrosine kinasequinoxaline derivativeantineoplastic activitybiological activitydrug cytotoxicitydrug synthesisdrug targetinghumannonhumanpriority journalReviewstructure activity relationantagonists and inhibitorschemical structurechemistrymolecular modelsynthesisAntineoplastic AgentsHumansModels, MolecularMolecular StructureProtein Kinase InhibitorsProtein-Tyrosine KinasesQuinoxalinesStructure-Activity RelationshipReviewhttps://doi.org/10.1002/ardp.201500468PubMed ID 27062086