Omar S.M.Abdel-Rashid R.S.AlAssaly M.K.Sakr T.M.Faculty of PharmacyAhram Canadian UniversityGizaEgypt; Department of Pharmaceutics and Industrial Pharmacy Faculty of PharmacyHelwan UniversityAin HelwanCairo11795Egypt; Ministry of InteriorMedical ServicesCairoEgypt; Faculty of PharmacyOctober University of Modern Sciences and ArtsCairoEgypt; Radioactive Isotopes and GeneratorsAtomic Energy AuthorityCairoEgypt2020-01-092020-01-09201915608115https://doi.org/10.1007/s40199-019-00275-2PubMed ID 31175641https://t.ly/BXJjXScopusMSA Google ScholarPurpose: Oral administration of Iodine?131 (I?131) solutions causes high risk of contamination for patients and dispensers. The objective of the study was to adapt hard gelatin capsules (HGCs) for filling with radiopharmaceutical solutions without deformation. Methods: Polystyrene (PS) internally lining films with different thicknesses were used to protect HGCs. The insulated HGCs were evaluated for their physicochemical characteristics and rupturing time in different dissolution media. HGCs internally lined with PS were examined for withstand loading with different volumes and radioactivities of I?131 solutions. Radioactivity release was studied in deionized water and acidic media. Quality control of released I?131 was inspected for radiochemical purities. Results: There was a directly proportion between PS lining thickness and stability of HGCs after filling with 500�?l aqueous methylene blue solution. HGCs internally lined with PS 100�?m thickness withstand deformation for ? two months; however showed fast in-vitro rupturing time in different dissolution media. Internally lined HGCs loaded with different volumes and radioactivities of I?131 solutions resisted for one week without radioactive leakage. Yet, revealed complete release of I?131 after 20�min in dissolution media with great radiochemical purity. Conclusion: The study promises safely I?131 aqueous solution delivery via adapted HGCs. [Figure not available: see fulltext.]. � 2019, Springer Nature Switzerland AG.EnglishOctober University for Modern Sciences and Artsجامعة أكتوبر للعلوم الحديثة والآدابUniversity of Modern Sciences and ArtsMSA UniversityAdaptationHard gelatin capsulesIodine?131 solutionLiningPolystyrenedeionized watergelatiniodine 131polystyrenegelatinradioactive iodineradiopharmaceutical agentaqueous solutionArticlebiofilmcontrolled studydrug delivery systemdrug releasedrug solubilityFourier transform infrared spectroscopyin vitro studymass fragmentographyphysical chemistryquality controlradiation measurementradiation stabilityradioactivityradiochemistrysolubilitychemistrydrug formulationhumanmicrocapsuleoral drug administrationAdministration, OralCapsulesDrug CompoundingGelatinHumansIodine RadioisotopesRadiopharmaceuticalsArticlehttps://doi.org/10.1007/s40199-019-00275-2PubMed ID 31175641