Abdou A.G.El Farargy S.Seleit I.Antar A.G.Elhefny M.Elnaidany N.F.Department of PathologyFaculty of MedicineMenofiya UniversityShebein ElkomEgypt; Department of Dermatology and AndrologyFaculty of MedicineMenofiya UniversityShebein ElkomEgypt; Department of Clinical PharmacyFaculty of PharmacyModern Sciences and Arts UniversityOctober CityEgypt2020-01-252020-01-2520128846812https://doi.org/https://t.ly/dOgyLScopusObjective: To explore the possible role of osteopontin (OPN) in chronic plaque psoriasis and understand the role of inflammation in psoriasis. STUDY DESIGN: We investigated 36 patients with chronic plaque psoriasis using immunohistochemical technique for evaluation of OPN immunolocalization compared to normal skin biopsies of 10 normal subjects representing the control group. Results: OPN was expressed in the epidermis of all specimens, both in the psoriasis group and the control group without any significant differences except for the tendency of psoriatic lesions to show more cytoplasmic and nuclear pattern of OPN staining (55.56%) compared to normal skin (20%). Epidermal strong and diffuse immunostaining of OPN was associated with the severity of psoriasis, and there was a correlation of the intensity of OPN expression with the density of the dermal inflammatory infiltrate. Conclusion: Our study suggests that OPN is involved in the pathophysiology of psoriasis, and a possible association with disease severity. OPN acts by different mechanisms through its expression by lesional keratinocytes, inflammatory cells, and endothelial cells. Nuclear localization of OPN may have a more significant role in the pathogenesis of psoriasis. � Science Printers and Publishers, Inc.EnglishInflammationOsteopontinPsoriasisosteopontinadultarticlecell nucleusclinical articlecontrolled studycorrelation analysiscytoplasmdisease associationdisease severityendothelium cellepidermisfemalehair folliclehumanimmunohistochemistryimmunolocalizationinflammatory cellinflammatory infiltratekeratinocytemalepathogenesispathophysiologypriority journalprotein expressionprotein localizationpsoriasis vulgarisPUVAsebaceous glandskin biopsysweat glandAdolescentAdultAgedBiopsyChildChronic DiseaseDermatitisFemaleHumansImmunohistochemistryMaleMiddle AgedOsteopontinPsoriasisSeverity of Illness IndexYoung AdultArticlehttps://doi.org/