Farag R.K.Labena A.Fakhry S.H.Safwat G.Diab A.Atta A.M.Petroleum Application DepartmentEgyptian Petroleum Research Institute (EPRI)Nasr CityCairo11727Egypt; Faculty of BiotechnologyOctober University for Modern Science and Arts26 July Mehwar Road intersection with Wahat Road6th October City P.O. Box 2511Egypt; Chemistry DepartmentCollege of ScienceKing Saud UniversityP.O. Box 2455Riyadh11451Saudi Arabia2020-01-092020-01-09201919961944https://doi.org/10.3390/ma12213604PubMedIDhttps://t.ly/AXXyXScopusGoogle ScholarIn the past few years, the development of hydrogel properties has led to the emergence of nanocomposite hydrogels that have unique properties that allow them to be used in various different fields and applications such as drug delivery, adsorption soil containing, tissue engineering, wound dressing, and especially antimicrobial applications. Thus, this study was conducted in order to fabricate a novel crosslinked terpolymer nanocomposite hydrogel using the free radical copolymerization method based on the usage of 2-acrylamido-2-methylpropane sulfonic acid (AMPS), acrylamide (AAm), acrylonitrile (AN), and acrylic acid (AA) monomers and iron oxide (Fe3O4) magnetic nanoparticles and using benzoyl peroxide as an initiator and ethylene glycol dimethacrylate (EGDMA) as a crosslinker. The structure of the synthesized composite was confirmed using Fourier transform infrared (FTIR) spectroscopy and x-ray powder diffraction (XRD) measurements. Furthermore, the surface morphology and the magnetic nanoparticle distributions were determined by scanning electron microscopy (SEM) measurement. In addition, the swelling capacity of the hydrogel nanocomposite was measured using the swelling test. Lastly, the efficiency of the produced composite was evaluated as an antimicrobial agent for Gram-positive and Gram-negative bacterial strains and a fungal strain. � 2019 by the authors.EnglishAntibacterialAntifungalIron oxide nanocompositeNanocomposite hydrogelsSwellingAcrylic monomersAmidesAntimicrobial agentsBenzoyl peroxideDrug deliveryEthyleneEthylene glycolFourier transform infrared spectroscopyFree radicalsIron oxidesMagnetiteMicroorganismsMorphologyNanocompositesNanomagneticsNanoparticlesScanning electron microscopySoil testingSurface morphologySwellingTerpolymersTissue engineeringX ray powder diffraction2-acrylamido-2-methylpropane sulfonic acidsAnti-fungalAntibacterialEthylene glycol dimethacrylateFree radical copolymerizationMagnetic nano-particlesNanocomposite hydrogelsTerpolymer nanocompositesHydrogelsArticlehttps://doi.org/10.3390/ma12213604PubMedID