Ezzat, Shahira MEl Bishbishy M.H.Habtemariam S.Salehi B.Sharifi-Rad M.Martins N.Sharifi-Rad J.Pharmacognosy DepartmentFaculty of PharmacyCairo UniversityKasr El-Ainy StreetCairo11562Egypt; Department of PharmacognosyFaculty of PharmacyOctober University for Modern Science and Arts (MSA)Cairo12566Egypt; Herbal Analysis Services UKPharmacognosy Research LaboratoriesUniversity of GreenwichCentral AvenueChatham-MaritimeKentME4 4TBUnited Kingdom; Student Research CommitteeBam University of Medical SciencesBam44340847Iran; Department of Medical ParasitologyZabol University of Medical SciencesZabol61663-335Iran; Institute for Research and Innovation in Health (i3S)University of PortoPorto4200-135Portugal; Faculty of MedicineUniversity of PortoAlameda Prof. Hern�ni MonteiroPorto4200-319Portugal; Zabol Medicinal Plants Research CenterZabol University of Medical SciencesZabol61615-585Iran; Department of ChemistryRichardson College for the Environmental Science ComplexUniversity of Winnipeg599 Portage AvenueWinnipegMB R3B 2G3Canada2020-01-092020-01-09201814203049https://doi.org/10.3390/molecules23123334PubMed ID 30558294https://t.ly/w18VdScopusMSA Google ScholarDiabetes mellitus (DM) is a chronic metabolic disease with high morbimortality rates. DM has two types: type 1, which is often associated with a total destruction of pancreatic beta cells, and non-insulin-dependent or type 2 diabetes mellitus (T2DM), more closely associated with obesity and old age. The main causes of T2DM are insulin resistance and/or inadequate insulin secretion. Protein-tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling pathways and plays an important role in T2DM, as its overexpression may induce insulin resistance. Thus, since PTP1B may be a therapeutic target for both T2DM and obesity, the search for novel and promising natural inhibitors has gained much attention. Hence, several marine organisms, including macro and microalgae, sponges, marine invertebrates, sea urchins, seaweeds, soft corals, lichens, and sea grasses, have been recently evaluated as potential drug sources. This review provides an overview of the role of PTP1B in T2DM insulin signaling and treatment, and highlights the recent findings of several compounds and extracts derived from marine organisms and their relevance as upcoming PTP1B inhibitors. In this systematic literature review, more than 60 marine-derived metabolites exhibiting PTP1B inhibitory activity are listed. Their chemical classes, structural features, relative PTP1B inhibitory potency (assessed by IC50 values), and structure�activity relationships (SARs) that could be drawn from the available data are discussed. The upcoming challenge in the field of marine research�metabolomics�is also addressed. � 2018 by the authors.EnglishInsulin signaling pathwaysMarine metabolitesProtein-tyrosine phosphatase 1BType 2 diabetes mellitusantidiabetic agentenzyme inhibitorprotein tyrosine phosphatase 1Banimalantagonists and inhibitorschemistryecosystemhumanisolation and purificationmetabolismAnimalsEcosystemEnzyme InhibitorsHumansHypoglycemic AgentsProtein Tyrosine Phosphatase, Non-Receptor Type 1Articlehttps://doi.org/10.3390/molecules23123334PubMed ID 30558294