Farag, Azza Gaber AntarShoeib, Mohamed Abd AlMoneamlabeeb, Azza ZagloulSleem, Asmaa ShaabanKhallaf, Hagar MKhalifa, Amany SalahElshaib, Mustafa ElsayedElnaidany, Nada FaragHanout, Hayam Mohamed Aboelnasr2023-01-032023-01-032022-12https://doi.org/10.1016/j.abd.2022.04.002http://repository.msa.edu.eg/xmlui/handle/123456789/5308Background: Vitiligo is an acquired depigmented skin disorder. It has a genetic and autoimmune background. Human beta defensin-1(HBD-1) plus its gene polymorphism were linked to some autoimmune disorders. Objective: To elucidate the possible role of HBD-1 in the pathogenesis of non-segmental vitiligo (NSV) through evaluation of HBD-1 serum levels and its single nucleotide polymorphism (SNP) in patients having NSV, in addition, to correlating the results with the extent of vitiligo in those patients. Methods: A current case-control study included 50 patients having NSV and 50 controls. The authors used Vitiligo Area Scoring Index (VASI) score to assess vitiligo severity and laboratory investigations to assess serum HBD-1 level using ELISA and defensin-beta1 (DEFB1) SNP using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).en-USGenes;Polymorphism,genetic;VitiligoArticlehttps://doi.org/10.1016/j.abd.2022.04.002