Lotfy, Hayam MSaleh, Sarah SRostom, YasminObaydo, Reem HAhmed, Dina A2024-09-082024-09-082024-01https://doi.org/10.1002/9781119889878.ch8http://repository.msa.edu.eg/xmlui/handle/123456789/6177The pharmaceutical industry and market have shown a tremendous evolution where different new pharmaceuticals and pharmaceutical combinations have been introduced in order to increase patient compliance and obtain the required outcomes. On the other hand, this evolution has raised a challenge in the field of drug analysis, where new applicable methods of analysis needed to be developed and validated to ensure that the right doses would reach patients free from any undesired compounds such as impurities, adulterants, or interfering substances that might lead to any undesirable side effects. This chapter highlights the advanced approaches in green univariate spectrophotometric methods based on basic mathematical techniques, such as subtraction, division, and multiplication, for assaying the components of multicomponent mixtures in their different pharmaceutical dosage forms utilising inexpensive, affordable, and eco-friendly facilities.enAGREE, Analytical GREEnness; Green analytical chemistry, GAC; Green Analytical Procedure Index, GAPI; National Environmental Methods Index NEMI; Ratio spectraBook chapterhttps://doi.org/10.1002/9781119889878.ch8