Ezzeldin Nagib, AbdelrahmanSaeed, Mostafa MohamedEl-Feky, Shereen FathyKhater Mohamed, Ali2022-03-252022-03-2501/01/2022https://doi.org/10.1007/978-3-030-87019-5_18http://repository.msa.edu.eg/xmlui/handle/123456789/4893ScopusCOVID-19 is one of the most dangerous diseases that appeared during the past 100 years, that caused millions of deaths worldwide. It caused hundreds of billions of losses worldwide as a result of complete business paralysis. This reason has attracted many researchers to attempt to find a suitable treatment for this dreaded virus. The search for a cure is still ongoing, but many researchers around the world have begun to search for the safest ways to detect if a person carries the virus or not. Many researchers resorted to artificial intelligence and machine learning techniques in order to detect whether a person is carrying the virus or not. However, many problems are arising when using these techniques, the most important problem is the optimal selection of the parameter values for these methods, as the choice of these values greatly affects the expected results. In this chapter, Differential Evolution algorithm is used to determine the optimal values for the hyperparameters of Convolutional Neural Networks, as Differential Evolution is one of the most efficient optimization algorithms in the last two decades. The results obtained showed that the use of Differential Evolution in optimizing the hyperparameters of the Convolutional Neural Network was very efficient.en-USConvolutional neural networkCOVID-19Differential EvolutionHyperparameters OptimizationArticlehttps://doi.org/10.1007/978-3-030-87019-5_18