S. Gad, Sameh2020-02-122020-02-122017References 1. Muthumani M, Prabu SM (2012) Silibinin potentially protects arsenic-induced oxidative hepatic dysfunction in rats. Toxicology Mechanisms and Methods 22(4): 277-288. 2. Thapa BR, Walia A (2007) Liver function tests and their interpretation. Indian Journal of Pediatrics 74(7): 663-671. 3. Bernal W, Wendon J (2013) Acute liver failure. The New England journal of medicine. 4. Stravitz RT, Kramer DJ (2009) Management of acute liver failure. Nat Rev Gastroenterol Hepatol 6: 542- 553. 5. American Society of Anesthesiologists (2012) Inc. Lippincott Williams & Wilkins. Anesthesiology 117: 898-904. 6. Hismiogullari SE, Hismiogullari AA, Sunay FB, Paksoy S, Can M, et al (2014) The protective effect of curcumin on carbon tetrachloride induced liver damage. Revue Méd Vét 165(7-8): 194-200. 7. Murphy SL, Xu JQ, Kochanek KD (2013) Deaths: Final data for 2010. Centers for Disease Control and Prevention website 61(3): 1-118. 8. AlwisD (2007) Genetics of alcoholic liver disease and nonalcoholic fatty liver disease. SeminLiver 27: 44- 54. 9. Bharrhan S, Chopra K, Rishi P (2010) Vitamin E Supplementation Modulates Endotoxin-induced Liver Damage in a Rat Model. American Journal of Biomedical Sciences 2(1): 51-62. 10. Venkatanarayana G, Sudhakara G, Rajeswaramma K, Indira P (2013) Combined effect of curcumin and vitamin E against CCl4 induced liver injury in rats. American Journal of Life Sciences 1(3): 117-124.https://doi.org/https://t.ly/AZjW7MSA Google ScholarThe liver is important, essential, and vital organ in the body due to their function in body. Detection of hepatic dysfunction depends on the lab tests such as: Elevated aspartate aminotransferase (AST) or alanine aminotransferase (ALT) and alkaline phosphatase (ALP). Curcumin has been shown to protect liver in much models of liver injury by inhibiting oxidative damage. Twenty four adult male albino rats their average weight 150-200 g were divided into four group six rats in each group ; group1: served as a normal group, group 2:subjected to 0.5mg/kg ccl4 dissolved in olive oil s.c every other day for 3 weeks, group 3:subjected to ccl40.5mg/kg dissolved in olive oil s.c every other day in addition to Curcumin 200 mg/kg /d orally every day for 3 weeks, group 4: subjected to ccl40.5 mg/kg dissolved in olive oil s.c every other day in addition to silymarin 200mg/kg orally every day for 3 weeks. The administration of ccl4 cause hepatic dysfunction and increase in serum ALT, AST and ALP level. The administration of Curcumin and silymarin along with ccl4 showed a decrease in serum ALT, AST and ALP level. The hepatic-protective effect of Curcumin and silymarin are relating to reduced liver enzymes as ALT, AST and ALP in hepatic dysfunction that produced by CCl4 toxicity through an antioxidant effects, exerting anti-inflammatory and free radical diminish.enUniversity of Hepatotoxicity; Carbon tetrachloride; Liver transaminases; Silymarine; CurcuminArticlehttps://doi.org/